MicroRNA expression distinguishes SCLC from NSCLC lung tumor cells and suggests a possible pathological relationship between SCLCs and NSCLCs.

Journal of Experimental & Clinical Cancer Research : CR
Liqin DuAlexander Pertsemlidis

Abstract

Recent studies have shown that microRNAs (miRNAs) play roles in tumorigenesis and are reliable classifiers of certain cancer types and subtypes. However, the role of miRNAs in the pathogenesis and diagnosis of small cell carcinoma (SCLC), the majority of which represent the most aggressive lung tumors, has not been investigated. In order to explore miRNA involvement in the pathogenesis of small cell lung carcinoma (SCLC) and the potential role of miRNAs in SCLC diagnosis, we compared the miRNA expression profile of a set of SCLC cell lines to that of a set of non-small cell lung cancer (NSCLC) cell lines and normal immortalized human bronchial epithelial cells (HBECs) using microarray analysis. Our results show that miRNA profiles reliably distinguish SCLC cell lines from NSCLC and HBEC cell lines. Further analysis of the miRNA expression profile of the two subtypes of lung cancer cell lines indicates that the expression levels of the majority of the miRNAs that are differentially expressed in SCLC cells relative to NSCLC cells and HBECs show a progressive trend from HBECs to NSCLC cells to SCLC cells. The distinctive miRNA expression signature of SCLCs relative to NSCLCs and HBECs suggests that miRNA profiles have the potentia...Continue Reading

References

Oct 1, 1976·Science·P C Nowell
Jan 1, 1996·Journal of Cellular Biochemistry. Supplement·R M PhelpsJ L Mulshine
Dec 6, 1996·Science·C J Sherr
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M B EisenD Botstein
Mar 4, 2003·Human Pathology·Mary Beth BeasleyElizabeth Brambilla
Jan 6, 2005·The Journal of Thoracic and Cardiovascular Surgery·Malcolm V BrockStephen C Yang
Mar 23, 2005·Nature Methods·J Michael ThomsonScott M Hammond
May 19, 2005·Seminars in Roentgenology·Mary Beth BeasleyWilliam D Travis
Oct 18, 2005·Lancet·David M Jackman, Bruce E Johnson
Oct 28, 2005·The New England Journal of Medicine·George Adrian CalinCarlo M Croce
Dec 31, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Hisao AsamuraKanji Nagai
Mar 15, 2006·Cancer Cell·Nozomu YanaiharaCurtis C Harris
Sep 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Claudia RoldoCarlo M Croce
Oct 25, 2006·Nature Reviews. Cancer·George A Calin, Carlo M Croce
Dec 5, 2006·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ruo-Kai LinYi-Ching Wang
Dec 13, 2006·American Journal of Respiratory and Critical Care Medicine·Adam GiangrecoSam M Janes
Aug 19, 2007·Cancer Research·Charles D JohnsonFrank J Slack
Sep 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Muller FabbriCarlo M Croce
Nov 28, 2007·Annual Review of Pathology·Ignacio I Wistuba, Adi F Gazdar
Jan 31, 2008·JAMA : the Journal of the American Medical Association·Aaron J SchetterCurtis C Harris
Mar 1, 2008·Proceedings of the National Academy of Sciences of the United States of America·Madhu S KumarTyler Jacks
Mar 5, 2008·Mayo Clinic Proceedings·Taimur SherAlex A Adjei
Mar 28, 2008·RNA·Anja M DuursmaReuven Agami
Jul 23, 2008·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·A H F MirnezamiG Packham
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patrick S MitchellMuneesh Tewari
Nov 11, 2008·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Shiyang PanZhong Chen
Nov 18, 2008·The European Respiratory Journal·C MascauxJ P Sculier
Dec 3, 2008·Biological Reviews of the Cambridge Philosophical Society·Niamh Lynam-LennonJohn V Reynolds
Feb 21, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Xi LiuEthan Dmitrovsky
Mar 11, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Danit LebanonyMahesh Mansukhani
May 14, 2009·Journal of Experimental & Clinical Cancer Research : CR·Tao YuXin-zhu Yi

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Citations

Jun 26, 2013·Biochimica Et Biophysica Acta·Marjan HarmsmaFrans C S Ramaekers
Feb 1, 2011·Journal of Molecular Cell Biology·Liqin Du, Alexander Pertsemlidis
Oct 9, 2012·American Journal of Respiratory and Critical Care Medicine·Wei HuangShao-hua Lu
Jul 7, 2011·PloS One·Jih-Hsiang LeeGiuseppe Giaccone
Jul 20, 2011·Clinical Chemistry and Laboratory Medicine : CCLM·Athina MarkouEvi Lianidou
Feb 12, 2013·Clinical Biochemistry·Ivan VanniniMuller Fabbri
May 23, 2012·Expert Opinion on Medical Diagnostics·Jun Shen, Feng Jiang
Aug 19, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kelsie L ThuWan L Lam
Jun 13, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·A MarkouE Lianidou
Jan 31, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Guang-Yuh ChiouShih-Hwa Chiou
May 5, 2011·Mutation Research·Marcin SkrzypskiJacek Jassem
Mar 1, 2011·Trends in Molecular Medicine·Elcie ChanJoanne Barnes Weidhaas
Mar 23, 2011·Translational Research : the Journal of Laboratory and Clinical Medicine·Sai Yendamuri, Robert Kratzke
Nov 20, 2015·Frontiers in Medicine·Srivatsava Naidu, Michela Garofalo
Aug 2, 2012·Genetics Research International·Katey S S EnfieldWan L Lam
May 15, 2012·Biochimica Et Biophysica Acta·Dorian R A SwartsErnst-Jan M Speel
Mar 25, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Karla A Ruiz-Ceja, Yolanda I Chirino
Nov 14, 2014·The Journal of Biological Chemistry·Hongwei LiangXi Chen
Jan 1, 2011·Cancers·Kenneth J O'ByrneSteven G Gray
Apr 21, 2018·Journal of Cellular Physiology·Arif Uddin, Supriyo Chakraborty
Mar 12, 2015·Nature Communications·Matthew J NiederstJeffrey A Engelman
May 28, 2019·Molecular Cancer·Xun LiXiaodong Ma
Jun 28, 2018·Neuroinformatics·Yatong JiangHujun Bian
Jun 13, 2020·Frontiers in Molecular Biosciences·Simone DetassisMichela Alessandra Denti
May 28, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Akbar Ghorbani AlvaneghHadi Esmaeili Gouvarchin Ghaleh

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