MicroRNA expression in Alzheimer blood mononuclear cells.

Gene Regulation and Systems Biology
Hyman M SchipperEugenia Wang

Abstract

Various coding genes representing multiple functional categories are downregulated in blood mononuclear cells (BMC) of patients with sporadic Alzheimer disease (AD). Noncoding microRNAs (miRNA) regulate gene expression by degrading messages or inhibiting translation. Using BMC as a paradigm for the study of systemic alterations in AD, we investigated whether peripheral miRNA expression is altered in this condition. MicroRNA levels were assessed using the microRNA microarray (MMChip) containing 462 human miRNA, and the results validated by real time PCR. Sixteen AD patients and sixteen normal elderly controls (NEC) were matched for ethnicity, age, gender and education. The expression of several BMC miRNAs was found to increase in AD relative to NEC levels, and may differ between AD subjects bearing one or two APOE4 alleles. As compared to NEC, miRNAs significantly upregulated in AD subjects and confirmed by qPCR were miR-34a and 181b. Predicted target genes downregulated in Alzheimer BMC that correlated with the upregulated miRNAs were largely represented in the functional categories of Transcription/Translation and Synaptic Activity. Several miRNAs targeting the same genes were within the functional category of Injury response/...Continue Reading

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Citations

Jan 14, 2020·Journal of Cellular and Molecular Medicine·Masoud BaghiKamran Ghaedi
Jul 18, 2020·International Journal of Molecular Sciences·Alex Cleber Improta-CariaBruno Solano de Freitas Souza
May 5, 2020·Frontiers in Neurology·Xianjuan KouNing Chen
Oct 28, 2017·Clinical Psychopharmacology and Neuroscience : the Official Scientific Journal of the Korean College of Neuropsychopharmacology·Mehmet Akif CamkurtEbru Fındıklı
Jul 1, 2020·Journal of Clinical Medicine·Daniel P ZalewskiAnna Bogucka-Kocka
Mar 22, 2020·International Journal of Molecular Sciences·Alessia IndrieriBrunella Franco
Jan 29, 2020·Current Neuropharmacology·Vivek Kumar SharmaThakur Gurjeet Singh
Feb 13, 2021·Biomolecules·Matea Nikolac PerkovicNela Pivac
Mar 13, 2021·Biochimica Et Biophysica Acta. Molecular Cell Research·Manon CallensTim Vervliet
Jan 22, 2021·Physiological Reviews·Camilla Ferrari, Sandro Sorbi

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Methods Mentioned

BETA
genotyping
chips
PCR

Software Mentioned

GSEA
Gene Set Enrichment Analysis ( GSEA )
GOTREE
SAM
Pro Analyzer
Array
GenePattern

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