MicroRNA expression profile of human advanced coronary atherosclerotic plaques

Scientific Reports
Mariana S ParahulevaGerhild Euler

Abstract

MicroRNA (miR) is reported to be involved in vascular inflammation and may represent a novel class of diagnostic biomarkers in cardiovascular disease. We aimed to identify the miR expression profile in human advanced coronary atherosclerotic plaques (CAP) and to connect this expression to the processes in atherosclerosis. Microarray techniques and TaqMan polymerase chain reaction were used to analyse the global expression of 352 miRs in CAP obtained during ACS MULTI-LINK study. 11 miRs were selected on the basis of their implication in atherosclerosis, endothelial activation, and inflammation. 6 miRs were found to be differently expressed in CAP when compared to non-atherosclerotic internal mammary arteries (IMA, p < 0.05). The expression of miR-21, -92a, and -99a was verified and found to be significantly up-regulated in CAP versus IMA (p < 0.001). We also performed bioinformatic analysis and found several potential target genes of miR-92a and -99a as well as several pathways with impact on atherosclerosis which could be differently expressed due to this miRNA profile. The most up-regulated miRs are involved in processes known to be connected to atherosclerosis. Interfering with the miR expression in the artery wall is a poten...Continue Reading

References

Jul 1, 1994·Journal of the American College of Cardiology·A E AbdelmeguidP L Whitlow
May 16, 2000·Arteriosclerosis, Thrombosis, and Vascular Biology·H C Stary
Dec 10, 2002·International Journal of Cardiovascular Interventions·J AM Te RieleP W Serruys
Dec 20, 2002·Nature·Peter Libby
May 12, 2004·The Journal of Experimental Medicine·Sucharita SenBanerjeeMukesh K Jain
Jun 24, 2004·Nature Reviews. Genetics·Lin He, Gregory J Hannon
May 20, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Tina RajAlex Agrotis
Nov 26, 2008·Nature Clinical Practice. Cardiovascular Medicine·Peter F Davies
Sep 18, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Emmanuel L GautierGwendalyn J Randolph
Jan 13, 2010·Nature Reviews. Cardiology·Kevin J Woollard, Frederic Geissmann
Jan 21, 2011·Nature·Eric M Small, Eric N Olson
Feb 16, 2011·Nature Immunology·Göran K Hansson, Andreas Hermansson
Aug 6, 2011·Stroke; a Journal of Cerebral Circulation·Francesco CipolloneFiamma Buttitta
Nov 23, 2011·Journal of Cellular Physiology·Tiziana ZottiRomania Stilo
Jan 24, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Yun Fang, Peter F Davies
Jan 12, 2013·Science·Filip K Swirski, Matthias Nahrendorf
Mar 8, 2013·Molecular and Cellular Biochemistry·Hua WangYuan Wang
May 24, 2013·The New England Journal of Medicine·Peter Libby
Oct 26, 2013·Current Atherosclerosis Reports·Xinghui SunMark W Feinberg
Nov 21, 2013·Circulation Research·Xavier LoyerAlain Tedgui
Jan 11, 2014·American Journal of Reproductive Immunology : AJRI·Ameya SatheKudumula Venkata Rami Reddy
Jun 18, 2014·The Journal of Clinical Endocrinology and Metabolism·Donato SantovitoFrancesco Cipollone
Jul 12, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Sandeep KumarHanjoong Jo
Oct 29, 2014·Journal of the American Heart Association·Felix JansenNikos Werner
Dec 3, 2014·Trends in Molecular Medicine·Emeline GorettiYvan Devaux
Mar 17, 2015·Trends in Molecular Medicine·Ioannis AndreouMark W Feinberg
Mar 31, 2015·Heart·Simon P R RomaineNilesh J Samani
May 15, 2015·Journal of Cellular and Molecular Medicine·Dimitry A ChistiakovAlexander N Orekhov
Jul 18, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Dong WangLars Maegdefessel
Aug 5, 2015·Journal of Vascular Surgery·Pierre MaitriasLaurent Metzinger
Nov 24, 2016·Immunobiology·Adam M ZawadaGunnar H Heine
Mar 23, 2017·American Journal of Reproductive Immunology : AJRI·Mitchell I Parker, Michael A Palladino
Aug 5, 2017·Arteriosclerosis, Thrombosis, and Vascular Biology·Pierre MaitriasLaurent Metzinger
Aug 30, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Shui-Chuan HuangShen-Ming Wang
Oct 11, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Wei-Qiang HuangFeng Huang
Oct 27, 2017·Cell Death & Disease·Andrea FelicianoMatilde E LLeonart

❮ Previous
Next ❯

Citations

Aug 8, 2019·Cardiovascular Research·Francesca FasoloJason L Johnson
Oct 10, 2019·Epigenomics·Öcal BerkanYvan Devaux
May 2, 2020·Journal of Cardiovascular Pharmacology and Therapeutics·Jennifer Y BarracloughSanjay Patel
Jun 4, 2020·Open Heart·Sandeep SinghSara-Joan Pinto-Sietsma
May 16, 2020·Antioxidants & Redox Signaling·Mohammed Rabiul HosenFelix Jansen
Nov 19, 2019·Journal of Cellular Biochemistry·Lijie ZhuChuanyu Gao
Dec 19, 2019·Journal of Clinical Medicine·Emma L SollyJoanne T M Tan
Nov 27, 2019·Arteriosclerosis, Thrombosis, and Vascular Biology·Maximillian A Rogers, Elena Aikawa
Aug 24, 2019·Frontiers in Cardiovascular Medicine·Eveline A C GoossensA Yaël Nossent
Jul 20, 2020·Cardiovascular Research·Suvi Linna-KuosmanenMinna U Kaikkonen
Nov 3, 2020·Cardiovascular Research·Andreas ZietzerFelix Jansen
Oct 23, 2020·Nutrition & Metabolism·Yang XiaoElizabeth R Gilbert
Aug 12, 2018·Journal of Molecular and Cellular Cardiology·Callum J DonaldsonLingfang Zeng
May 7, 2021·Oxidative Medicine and Cellular Longevity·Md Sayed Ali SheikhIbrahim A M Abdulhabeeb
May 14, 2021·Arteriosclerosis, Thrombosis, and Vascular Biology·Pierre R MoreauMinna U Kaikkonen

❮ Previous
Next ❯

Methods Mentioned

BETA
percutaneous directional coronary atherectomy
coronary bypass
PCR
Assay
coronary artery bypass

Software Mentioned

PicTar
ORBITA
NormFinder
GraphPad Prism
TargetScan
GraphPad
TargetScan PicTar

Related Concepts

Related Feeds

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.