MicroRNA Expression Profiling in Psoriatic Arthritis

BioMed Research International
Andrea PelosiMarzia Dolcino

Abstract

Psoriatic arthritis (PsA) is an inflammatory arthritis, characterized by bone erosions and new bone formation. MicroRNAs (miRNAs) are key regulators of the immune responses. Differential expression of miRNAs has been reported in several inflammatory autoimmune diseases; however, their role in PsA is not fully elucidated. We aimed to identify miRNA expression signatures associated with PsA and to investigate their potential implication in the disease pathogenesis. miRNA microarray was performed in blood cells of PsA patients and healthy controls. miRNA pathway analyses were performed and the global miRNA profiling was combined with transcriptome data in PsA. Deregulation of selected miRNAs was validated by real-time PCR. We identified specific miRNA signatures associated with PsA patients with active disease. These miRNAs target pathways relevant in PsA, such as TNF, MAPK, and WNT signaling cascades. Network analysis revealed several miRNAs regulating highly connected genes within the PsA transcriptome. miR-126-3p was the most downregulated miRNA in active patients. Noteworthy, miR-126 overexpression induced a decreased expression of genes implicated in PsA. This study sheds light on some epigenetic aspects of PsA identifying sp...Continue Reading

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Jun 11, 2019·Expert Review of Clinical Immunology·Maria Sole ChimentiRoberto Perricone
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Methods Mentioned

BETA
ELISA
Transfection
PCR
biopsies

Software Mentioned

QuantStudio Real - Time PCR
miRPath
TargetScan
Gene Spring
AmiGO
DIANA
Tarbase

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