MicroRNA Expression Signature in Human Calcific Aortic Valve Disease

BioMed Research International
Hui WangYihua Bei

Abstract

Altered microRNA (miRNA, miR) expression has been related to many disease processes; however, the miRNA expression signature in calcific aortic valve disease (CAVD) is unclear. In this study, microarrays were used to determine the miRNA expression signature of tissue samples from healthy individuals (n= 4) and patients with CAVD (n= 4). TargetScan, PITA, and microRNAorg 3-way databases were used to predict the potential target genes. DIANA-miRPath was used to incorporate the aberrant miRNAs into gene pathways. miRNA microarrays identified 92 differentially expressed miRNAs in CAVD tissues. The principal component analysis (PCA) of these samples and the unsupervised hierarchical clustering analysis based on the 92 aberrantly expressed miRNAs noted that miRNA expression could be categorized into two well-defined clusters that corresponded to healthy control and CAVD. Bioinformatic analysis showed the miRNA targets and potential molecular pathways. Collectively, our study reported the miRNA expression signature in CAVD and may provide potential therapeutic targets for CAVD.

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Citations

Jun 19, 2018·Journal of Developmental Origins of Health and Disease·B SiddeekU Simeoni
Nov 7, 2019·Current Pharmaceutical Design·Mahesh Mundalil VasuAyyappan Anitha
Nov 22, 2018·Frontiers in Cardiovascular Medicine·Vinal Menon, Joy Lincoln
Jul 12, 2019·Frontiers in Cardiovascular Medicine·Jana PetrkovaMartin Petrek

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Software Mentioned

miRPath
TargetScan
MicroRNAorg
DIANA
PITA

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