Aug 23, 2005

MicroRNA function in animal development

FEBS Letters
Erno Wienholds, Ronald H A Plasterk

Abstract

MicroRNAs (miRNAs) are small non-coding RNA molecules that post-transcriptionally regulate gene expression by base-pairing to mRNAs. Hundreds of miRNAs have been identified in various multicellular organisms and many miRNAs are evolutionarily conserved. Although the biological functions of most miRNAs are unknown, miRNAs are predicted to regulate up to 30% of the genes within the human genome. Gradually, we are beginning to understand the functions of individual miRNAs and the general function of miRNA action. Here, we review the recent advances in miRNA biology in animals. Particularly, we focus on the roles of miRNAs in vertebrate development and disease.

  • References145
  • Citations408

References

  • References145
  • Citations408

Citations

Mentioned in this Paper

Vertebrates
MRNA Cleavage
Calcinus elegans
Embryo
Cyartonema elegans
Zinc Fingers
Coleonyx elegans
Biochemical Pathway
Receptors, Notch
Microarray Analysis

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