MicroRNA gene regulatory pathways in the establishment and maintenance of ESC identity.

Cell Stem Cell
Natalia J Martinez, Richard I Gregory

Abstract

Understanding the molecular foundations of embryonic stem cell (ESC) self-renewal and pluripotency will facilitate therapeutic exploitation of these remarkable cells. Here we discuss the emerging roles of microRNAs in the establishment and maintenance of ESC identity and summarize our current understanding of the mechanisms controlling microRNA expression and function in ESCs.

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Methods Mentioned

BETA
antisense oligonucleotides

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