MicroRNA in Brain pathology: Neurodegeneration the Other Side of the Brain Cancer

Non-coding RNA
Jakub GodlewskiElzbieta Salinska

Abstract

The mammalian brain is made up of billions of neurons and supporting cells (glial cells), intricately connected. Molecular perturbations often lead to neurodegeneration by progressive loss of structure and malfunction of neurons, including their death. On the other side, a combination of genetic and cellular factors in glial cells, and less frequently in neurons, drive oncogenic transformation. In both situations, microenvironmental niches influence the progression of diseases and therapeutic responses. Dynamic changes that occur in cellular transcriptomes during the progression of developmental lineages and pathogenesis are controlled through a variety of regulatory networks. These include epigenetic modifications, signaling pathways, and transcriptional and post-transcriptional mechanisms. One prominent component of the latter is small non-coding RNAs, including microRNAs, that control the vast majority of these networks including genes regulating neural stemness, differentiation, apoptosis, projection fates, migration and many others. These cellular processes are also profoundly dependent on the microenvironment, stemness niche, hypoxic microenvironment, and interactions with associated cells including endothelial and immune...Continue Reading

References

Mar 1, 1989·Critical Care Nursing Quarterly·D E Craven, A M Regan
Jun 24, 2004·Nature Reviews. Genetics·Lin He, Gregory J Hannon
Jul 24, 2004·Nature Medicine·Ella Bossy-WetzelStuart A Lipton
Oct 7, 2004·Cancer Research·Hiroko OhgakiPaul Kleihues
Nov 19, 2004·Nature·Sheila K SinghPeter B Dirks
Apr 23, 2005·The European Journal of Neuroscience·Lena SmirnovaF Gregory Wulczyn
Jul 26, 2005·Biochemical and Biophysical Research Communications·S A CiafrèM G Farace
Aug 17, 2005·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Pasan FernandoLynn A Megeney
Oct 18, 2005·Cancer Cell·Michael D TaylorRichard J Gilbertson
Oct 18, 2005·Nature Cell Biology·Christopher WynderRamin Shiekhattar
Dec 17, 2005·Stem Cells·Anna M KrichevskyKenneth S Kosik
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stefano VoliniaCarlo M Croce
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Cecilia ConacoGail Mandel
May 26, 2006·Nature Reviews. Cancer·Angelo L VescoviBrent A Reynolds
Jun 1, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Monika DeoDavid L Turner
Dec 30, 2006·Molecular and Cellular Biology·Ritu KulshreshthaMircea Ivan
Apr 25, 2007·Nature Reviews. Neuroscience·Karl Herrup, Yan Yang
Apr 26, 2007·The American Journal of Pathology·Hiroko Ohgaki, Paul Kleihues
Sep 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Hiroshi TazawaHitoshi Nakagama
Sep 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Muller FabbriCarlo M Croce
Oct 30, 2007·Proceedings of the National Academy of Sciences of the United States of America·Harpreet Kaur SainiAnton James Enright
Nov 3, 2007·Genes & Development·Frank B FurnariWebster K Cavenee
Apr 18, 2008·The Journal of Biological Chemistry·Pasquale FasanaroFabio Martelli
Apr 25, 2008·Proceedings of the National Academy of Sciences of the United States of America·Sébastien S HébertBart De Strooper
May 24, 2008·Molecular Cell·Ulf Andersson ØromAnders H Lund
Aug 23, 2008·Cell Cycle·Dmitri LodyginHeiko Hermeking
Oct 3, 2008·Cancer Research·Thales PapagiannakopoulosKenneth S Kosik
Jan 2, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Amy N PackerBeverly L Davidson
Feb 26, 2009·Cell·Richard W Carthew, Erik J Sontheimer
Mar 31, 2009·Cold Spring Harbor Symposia on Quantitative Biology·J N Rich, C E Eyler
May 22, 2009·Neuromolecular Medicine·Rory Johnson, Noel J Buckley
Jul 25, 2009·Proceedings of the National Academy of Sciences of the United States of America·Eunsung JunnM Maral Mouradian
Oct 24, 2009·Nature Reviews. Cancer·Adrian P Bracken, Kristian Helin
Dec 25, 2009·Nature·Maria Stella CarroAntonio Iavarone
Jan 13, 2010·Cold Spring Harbor Perspectives in Biology·Jack T Zilfou, Scott W Lowe
Jan 15, 2010·Journal of Cellular and Molecular Medicine·Kurt A Jellinger
May 12, 2010·Biochemical Pharmacology·Lin ChengJeremy N Rich

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Citations

Feb 12, 2020·International Journal of Environmental Research and Public Health·Md Habibur RahmanMohammad Ali Moni
Sep 11, 2020·Cancers·Akilandeswari A BalachandranRakesh N Veedu
Mar 7, 2020·International Journal of Molecular Sciences·Metka Ravnik-Glavač, Damjan Glavač
Aug 1, 2019·Current Neuropharmacology·Antonietta SantoroRosaria Meccariello
Aug 28, 2019·International Journal of Molecular Sciences·Andrea DianaDaniela Murtas
Oct 9, 2020·Asia-Pacific Journal of Clinical Oncology·Tayyebali SalmaniReza Akbarzadeh
Feb 18, 2021·Biomedical Engineering Online·Leonardo J Galvão-LimaElio J S S Barreto
Dec 16, 2021·Expert Review of Molecular Diagnostics·Amir Hossein AalamiAmirhossein Sahebkar

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Methods Mentioned

BETA
transgenic
xenograft

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