MicroRNA in Lung Cancer Metastasis

Cancers
Shang-Gin WuJin-Yuan Shih

Abstract

Tumor metastasis is a hallmark of cancer, with distant metastasis frequently developing in lung cancer, even at initial diagnosis, resulting in poor prognosis and high mortality. However, available biomarkers cannot reliably predict cancer spreading sites. The metastatic cascade involves highly complicated processes including invasion, migration, angiogenesis, and epithelial-to-mesenchymal transition that are tightly controlled by various genetic expression modalities along with interaction between cancer cells and the extracellular matrix. In particular, microRNAs (miRNAs), a group of small non-coding RNAs, can influence the transcriptional and post-transcriptional processes, with dysregulation of miRNA expression contributing to the regulation of cancer metastasis. Nevertheless, although miRNA-targeted therapy is widely studied in vitro and in vivo, this strategy currently affords limited feasibility and a few miRNA-targeted therapies for lung cancer have entered into clinical trials to date. Advances in understanding the molecular mechanism of metastasis will thus provide additional potential targets for lung cancer treatment. This review discusses the current research related to the role of miRNAs in lung cancer invasion an...Continue Reading

References

Jan 1, 1983·Cancer Metastasis Reviews·I Carr
May 23, 1998·Genes, Chromosomes & Cancer·T KohnoJ Yokota
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Jul 27, 2000·The New England Journal of Medicine·R M PietermanH J Groen
Jan 13, 2001·The Annals of Thoracic Surgery·H AsamuraR Tsuchiya
May 15, 2002·Current Biology : CB·Mariana Lagos-QuintanaThomas Tuschl
Aug 3, 2002·Science·György Hutvágner, Phillip D Zamore
Aug 3, 2002·Nature Reviews. Cancer·Gregory R Mundy
Aug 22, 2002·Nature Reviews. Cancer·Jean Paul Thiery
Jun 18, 2003·Cell·Yigong Shi, Joan Massagué
Jul 29, 2003·Journal of Mammary Gland Biology and Neoplasia·Martin JechlingerHartmut Beug
Apr 16, 2004·The New England Journal of Medicine·G David Roodman
Jun 10, 2005·Nature·Jun LuTodd R Golub
Nov 1, 2005·Nature·Jan KrützfeldtMarkus Stoffel
Nov 30, 2005·Nucleic Acids Research·Cindy VandewalleGeert Berx
Jan 10, 2006·Science·Gary Ruvkun
Oct 25, 2006·Nature Reviews. Cancer·George A Calin, Carlo M Croce
Apr 24, 2007·Advanced Drug Delivery Reviews·Lars Aagaard, John J Rossi
Sep 19, 2007·Proceedings of the National Academy of Sciences of the United States of America·Hiroshi TazawaHitoshi Nakagama
Jan 3, 2008·Cancer Cell·Sung-Liang YuPan-Chyr Yang
Jun 10, 2008·Developmental Cell·Jing Yang, Robert A Weinberg
Aug 6, 2008·Proceedings of the National Academy of Sciences of the United States of America·Shuang TangPhilip R Krause
Aug 21, 2008·Angewandte Chemie·Kiranmai GumireddyAlexander Deiters
Dec 23, 2008·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·E A EisenhauerJ Verweij
Feb 5, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Helena Grinberg-RashiShai Izraeli
Jun 3, 2009·The Journal of Clinical Investigation·Raghu Kalluri, Robert A Weinberg
Jun 3, 2009·The Journal of Clinical Investigation·Hervé AcloqueM Angela Nieto
Jun 26, 2009·Expert Opinion on Drug Delivery·Xiubo ZhaoJian R Lu
Nov 26, 2009·Nature Cell Biology·Ulrich WellnerThomas Brabletz
Dec 1, 2009·Cell·Jean Paul ThieryM Angela Nieto

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Citations

Jun 27, 2019·QJM : Monthly Journal of the Association of Physicians·A AbdollahiM Abdi
Oct 2, 2019·Current Molecular Medicine·Parisa NaeliHamed Mirzaei
Apr 23, 2020·Frontiers in Oncology·Ilias Georgakopoulos-SoaresApostolos Zaravinos
Oct 9, 2019·British Journal of Biomedical Science·P Waller, A D Blann
Oct 1, 2020·International Journal of Molecular Sciences·Vu Hong Loan NguyenChun Peng
May 18, 2020·Journal of Cell Communication and Signaling·Amir Mokhlesi, Mahmood Talkhabi
Feb 13, 2021·Journal of Personalized Medicine·Carlos Pérez-SánchezAntonio Rodríguez-Ariza
Nov 26, 2020·International Journal of Molecular Sciences·Young-Ho Ahn, Yoon Ho Ko
Feb 7, 2021·Journal of Personalized Medicine·Rakhmetkazhy BersimbaevOralbek Ilderbayev
Apr 4, 2021·Biomedicines·Ying-Chin LinJung-Chun Lin
Apr 9, 2021·Life Sciences·Pawan Kumar Raghav, Zoya Mann
Apr 21, 2021·Molecular Biology Reports·Qian LiFrederick T Greenaway
May 9, 2021·Analytical Biochemistry·Bin WenKui Zhao
Jun 3, 2021·Briefings in Bioinformatics·Zulkar NainSudhangshu Kumar Biswas
Jun 19, 2021·Molecular Therapy. Nucleic Acids·Shu-Hsuan LiuWei-Chung Cheng

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Methods Mentioned

BETA
xenograft
antisense oligonucleotides

Clinical Trials Mentioned

NCT01829971
NCT02862145
NCT02369198
NCT02716012

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