MicroRNA in pancreatic ductal adenocarcinoma and its precursor lesions

World Journal of Gastrointestinal Oncology
Yasmin G Hernandez, Aimee L Lucas

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is the 4(th) deadliest cancer in the United States, due to its aggressive nature, late detection, and resistance to chemotherapy. The majority of PDAC develops from 3 precursor lesions, pancreatic intraepithelial lesions (PanIN), intraductual papillary mucinous neoplasm (IPMN), and mucinous cystic neoplasm. Early detection and surgical resection can increase PDAC 5-year survival rate from 6% for Stage IV to 50% for Stage I. To date, there are no reliable biomarkers that can detect PDAC. MicroRNAs (miRNA) are small noncoding RNAs (18-25 nucleotides) that regulate gene expression by affecting translation of messenger RNA (mRNA). A large body of evidence suggests that miRNAs are dysregulated in various types of cancers. MiRNA has been profiled as a potential biomarker in pancreatic tumor tissue, blood, cyst fluid, stool, and saliva. Four miRNA biomarkers (miR-21, miR-155, miR-196, and miR-210) have been consistently dysregulated in PDAC. MiR-21, miR-155, and miR-196 have also been dysregulated in IPMN and PanIN lesions suggesting their use as early biomarkers of this disease. In this review, we explore current knowledge of miRNA sampling, miRNA dysregulation in PDAC and its precursor lesions...Continue Reading

Citations

Oct 25, 2016·Laboratory Investigation; a Journal of Technical Methods and Pathology·Famke AeffnerG David Young
Dec 14, 2016·Future Medicinal Chemistry·Francesca Aredia, Anna Ivana Scovassi
Feb 12, 2017·Carcinogenesis·Shinichi KannoHiroshi Nakase
Feb 28, 2017·International Journal of Cancer. Journal International Du Cancer·Bin ZhouHan-Xiang Zhan
Feb 13, 2017·Digestive Endoscopy : Official Journal of the Japan Gastroenterological Endoscopy Society·Carlo FabbriDario de Biase
Jun 18, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sven H LoosenTom Luedde
Jun 15, 2017·Gut and Liver·Sara Welinsky, Aimee L Lucas
Mar 28, 2017·Clinical Chemistry and Laboratory Medicine : CCLM·Francine B de AbreuGregory J Tsongalis
Jul 28, 2019·Cancers·Iranzu González-BorjaJoaquin Fernández-Irigoyen
Mar 29, 2020·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Xin ChangDe-Feng Li
Feb 16, 2017·Digestive Diseases and Sciences·Harkirat SinghAatur D Singhi
Sep 7, 2018·Canadian Journal of Gastroenterology & Hepatology·Lumir KunovskyJan Trna
Aug 28, 2019·Oncology Letters·Qian ZhangShan Liang Zhong
May 23, 2018·Journal of Translational Medicine·Tiphaine de FoucherCyril Touboul
Nov 5, 2019·Biochimica Et Biophysica Acta. Reviews on Cancer·Joseph CarmichealSurinder K Batra
Mar 7, 2021·Journal of Personalized Medicine·Beste TuranliRaghu Sinha
Apr 9, 2021·Translational Oncology·Maria MortoglouPinar Uysal-Onganer
May 1, 2021·Biomolecules·Concetta PanebiancoValerio Pazienza

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved