MicroRNA let‑7d‑5p rescues ovarian cancer cell apoptosis and restores chemosensitivity by regulating the p53 signaling pathway via HMGA1

International Journal of Oncology
Yan-Nan ChenYan Liu

Abstract

Ovarian cancer (OC) is the gynecological malignancy type with the highest mortality rate in females. The regulatory effect of microRNAs (miRs) on their target genes serves a key role in tumor development. Therefore, in the present study, whether miR let‑7d‑5p targeting high mobility group A1 (HMGA1) regulated biological characteristics and chemosensitivity of OC cells by mediating the p53 signaling pathway was investigated. The let‑7d‑5p level was detected in OC tissues and adjacent normal tissues, followed by detection in OC cell lines SKOV3, A2780, OVCAR‑3 and CaOV3, and human normal ovarian epithelial cell line (IOSE‑80), in order to select the OC cell line for the following experiments. Subsequently, OC cells were treated with the let‑7d‑5p mimic, siHMGA1 and Tenovin‑1. The targeting association between let‑7d‑5p and HMGA1 was then examined, and the OC cell viability, migration, cycle and apoptosis were evaluated. Subsequently, the chemosensitivity of OC cells to cisplatin was verified. Finally, expression levels of let‑7d‑5p, HMGA1, p21, B‑cell lymphoma‑2 (Bcl‑2)‑associated X (Bax), p27, p53 wild‑type (p53wt), p53 mutated (p53mut), proliferating cell nuclear antigen (PCNA), cyclin‑dependent kinase 2 (CDK2), matrix metallop...Continue Reading

References

Feb 16, 2010·The American Journal of Surgical Pathology·Robert J Kurman, Ie-Ming Shih
Mar 26, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Aurora AielloAntonino Belfiore
Apr 17, 2010·American Journal of Respiratory and Critical Care Medicine·Kusum V PanditNaftali Kaminski
Apr 28, 2011·CA: a Cancer Journal for Clinicians·Danijela Jelovac, Deborah K Armstrong
May 10, 2011·Molecular Cancer·Håkon RambergKristin Austlid Taskén
Jul 2, 2011·Nature·UNKNOWN Cancer Genome Atlas Research Network
Aug 13, 2011·The Lancet Oncology·Hui-Wen LinYuen-Liang Lai
Sep 10, 2011·The Journal of Biological Chemistry·Zifeng WangMarie Chia-mi Lin
Oct 11, 2011·Cancer Research·Young-Ah SuhGuillermina Lozano
Jan 14, 2012·Expert Opinion on Therapeutic Targets·Alexander H Stegh
Feb 22, 2012·Clinical Obstetrics and Gynecology·David M Gershenson
Feb 22, 2012·Clinical Obstetrics and Gynecology·Michael A Bookman
Jun 16, 2012·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Gerard J NuovoMatthew C Coffey
Aug 16, 2013·Oncotarget·Silvia PegoraroGuidalberto Manfioletti
Jan 8, 2014·Journal of Translational Medicine·Miharu KobayashiGregory E Rice
Sep 13, 2014·Cancer Chemotherapy and Pharmacology·Alvaro Henrique Ingles GarcesAndréia Cristina de Melo
Oct 4, 2014·Genes, Chromosomes & Cancer·Casina W S KanDeborah J Marsh
Jan 15, 2015·Cancer Biomarkers : Section a of Disease Markers·Jun ZhouJifang Wen
Feb 24, 2015·Journal of Cellular Biochemistry·Barbara RohmVeronika Somoza
Mar 17, 2015·Molecular and Cellular Biochemistry·Ruixue HuangFei Yang
Mar 31, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Junnai WangQiang Li
Jun 13, 2015·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Xiaozhan ZhangLiandong Qu
Jun 14, 2016·Journal of Photochemistry and Photobiology. B, Biology·Sandra M AyukNicolette N Houreld
Jul 3, 2016·Reproductive Sciences·Anxin GuE Mingyan
Aug 9, 2016·Journal of Geriatric Oncology·William P Tew
Aug 27, 2016·Experimental & Molecular Medicine·Dae Kyoung KimJae Ho Kim
Dec 29, 2016·Proceedings of the National Academy of Sciences of the United States of America·Susanne MilatzDorothee Günzel
Jan 21, 2017·Oncoscience·Marina BagnoliDelia Mezzanzanica
Apr 7, 2017·ACS Applied Materials & Interfaces·Clément AnfraySamuel Valable
Feb 1, 2017·Reproductive Sciences·Anxin GuE Mingyan

❮ Previous
Next ❯

Citations

Jan 26, 2020·International Journal of Molecular Sciences·Riccardo SgarraAnd Guidalberto Manfioletti
Jan 23, 2020·International Journal of Molecular Sciences·Robert Vignali, Silvia Marracci
Nov 27, 2019·Cancers·Mudra BinjuYu Yu
Apr 4, 2021·Cancers·Shailendra Kumar Dhar DwivediResham Bhattacharya
Apr 20, 2021·Frontiers in Immunology·Xueqin ZouQixiang Shao
Jul 19, 2021·Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids·Richard J LightbodyAnnette Graham
Jul 25, 2021·International Journal of Molecular Sciences·Chiara De Santis, Martin Götte
Jul 25, 2021·Cancers·Aya Saleh, Ruth Perets

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.