MicroRNA-modulated autophagic signaling networks in cancer

The International Journal of Biochemistry & Cell Biology
Lei-lei FuB Liu

Abstract

MicroRNAs (miRNAs) are small, non-coding endogenous RNAs ∼22 nucleotides (nt) in length that may play the essential roles for regulation of programed cell death, referring to apoptosis and autophagy. Of note, autophagy is an evolutionarily conserved, multi-step lysosomal degradation process in which a cell degrades long-lived proteins and damaged organelles. Accumulating evidence has recently revealed that miRNAs can modulate the autophagic pathways in many pathological processes, most notably cancer. In this review, we focus on highlighting the dual functions of miRNAs as either oncogenes (e.g., miRNA-183, miRNA-376b, miRNA-106a, miRNA-221/222, miRNA-31 and miRNA-34c) or tumor suppressors (e.g., miRNA-30a, miRNA-101 and miRNA-9*) via mediating several autophagic signaling pathways in cancer pathogenesis. Taken together, these findings may uncover the regulatory mechanisms of oncogenic and tumor suppressive miRNAs in autophagy, which would provide a better understanding of miRNA-modulated autophagic signaling networks for future cancer therapeutics.

References

Apr 20, 2007·The Journal of Biological Chemistry·Guillermo MariñoCarlos López-Otín
Aug 3, 2007·Cell Cycle·Ju Huang, Daniel J Klionsky
Jan 15, 2008·Cell·Beth Levine, Guido Kroemer
Aug 19, 2008·The Journal of Biological Chemistry·Tyler E MillerSarmila Majumder
Apr 18, 2009·Biochimica Et Biophysica Acta·Eugenia MorselliGuido Kroemer
Nov 26, 2009·Biochimica Et Biophysica Acta·William C S Cho
Mar 17, 2010·The International Journal of Biochemistry & Cell Biology·Anita G Seto
Aug 10, 2010·Acta Pharmacologica Sinica·Bo LiuJin-Ming Yang
Dec 15, 2010·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Raquel T LimaM Helena Vasconcelos
Jan 7, 2011·Expert Opinion on Therapeutic Targets·Paolo GandelliniNadia Zaffaroni
Feb 12, 2011·Cell Death and Differentiation·R KangD Tang
Feb 15, 2011·International Journal of Cardiology·Xiao JianNi Xin
May 31, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Deepak AbrahamStan B Sidhu
Jun 7, 2011·The International Journal of Biochemistry & Cell Biology·Shu-ya WangBo Liu
Sep 15, 2011·The EMBO Journal·Lisa B FrankelAnders H Lund
Sep 29, 2011·Biochemical and Biophysical Research Communications·Zi-yue LiBo Liu

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Citations

May 15, 2012·Applied Biochemistry and Biotechnology·Nan WangJin-ku Bao
Feb 20, 2013·The International Journal of Biochemistry & Cell Biology·Lei-lei FuBo Liu
Jul 4, 2013·The International Journal of Biochemistry & Cell Biology·Bo LiuYuquan Wei
Apr 9, 2013·Acta Pharmacologica Sinica·Xin LiJin-ku Bao
Jul 12, 2013·Cancer Biotherapy & Radiopharmaceuticals·Banzhou PanHaizhu Song
Jun 6, 2013·Future Medicinal Chemistry·Francesca Aredia, A Ivana Scovassi
Jul 28, 2012·Chinese Journal of Cancer·Bo LiuYan Cheng
Feb 23, 2013·Biochimica Et Biophysica Acta·Jianzhou CuiHan-Ming Shen
Feb 18, 2016·BMC Cancer·Michelle J NyhanSharon L McKenna
Sep 12, 2015·Expert Opinion on Therapeutic Targets·Yoon Yang JungJa Seung Koo
Mar 29, 2014·Journal of Cellular Physiology·Nicoletta MarchesiSergio Comincini
Feb 13, 2016·International Journal of Molecular Sciences·Zheng ShiYong Tang
Mar 11, 2015·Journal of Cellular Physiology·Zhang SuzhiWang Qin
Sep 28, 2013·Gastroenterology·Massimo Donadelli, Marta Palmieri
Jun 14, 2015·Biochemical and Biophysical Research Communications·Min-Bin ChenYe Tian
Oct 15, 2013·International Journal of Cancer. Journal International Du Cancer·Vanessa Lopes-RodriguesM Helena Vasconcelos
Aug 6, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sheng-Hui LanHsiao-Sheng Liu
Sep 15, 2012·Journal of Ovarian Research·Claudia PeracchioCiro Isidoro
Oct 21, 2014·Cell Proliferation·Y ChenL Ouyang
Dec 19, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Saumya Pandey, Chandravati
Sep 1, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Vildan Bozok ÇetintaşZuhal Eroğlu
Jul 15, 2015·Experimental Cell Research·Xiujuan LiuXiangmei Chen
May 2, 2015·Apoptosis : an International Journal on Programmed Cell Death·Yi ChenBo Liu
Jan 17, 2013·Autophagy·Kumsal Ayse TekirdagDevrim Gozuacik
Dec 21, 2012·Cell Cycle·Haiyan ZhaiJingfang Ju
Jul 4, 2012·The International Journal of Biochemistry & Cell Biology·Lingchao ChenChuanlu Jiang
Jan 9, 2016·ScienceOpen Research·Yongfei Yang, Chengyu Liang
Feb 26, 2015·Biochemical and Biophysical Research Communications·Bing ZhengYuxi Shan
Apr 10, 2015·PloS One·Emmanouil RizosVassilios Zoumpourlis
Jun 18, 2016·Cancer Biomarkers : Section a of Disease Markers·Huangyan ZhouDian Gao

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