MicroRNA modulated networks of adaptive and innate immune response in pancreatic ductal adenocarcinoma

PloS One
Tainara F FelixPatricia P Reis

Abstract

Despite progress in treatment strategies, only ~24% of pancreatic ductal adenocarcinoma (PDAC) patients survive >1 year. Our goal was to elucidate deregulated pathways modulated by microRNAs (miRNAs) in PDAC and Vater ampulla (AMP) cancers. Global miRNA expression was identified in 19 PDAC, 6 AMP and 25 paired, histologically normal pancreatic tissues using the GeneChip 4.0 miRNA arrays. Computational approaches were used for miRNA target prediction/identification of miRNA-regulated pathways. Target gene expression was validated in 178 pancreatic cancer and 4 pancreatic normal tissues from The Cancer Genome Atlas (TCGA). 20 miRNAs were significantly deregulated (FC≥2 and p<0.05) (15 down- and 5 up-regulated) in PDAC. miR-216 family (miR-216a-3p, miR-216a-5p, miR-216b-3p and miR-216b-5p) was consistently down-regulated in PDAC. miRNA-modulated pathways are associated with innate and adaptive immune system responses in PDAC. AMP cancers showed 8 down- and 1 up-regulated miRNAs (FDR p<0.05). Most enriched pathways (p<0.01) were RAS and Nerve Growth Factor signaling. PDAC and AMP display different global miRNA expression profiles and miRNA regulated networks/tumorigenesis pathways. The immune response was enriched in PDAC, suggesti...Continue Reading

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Citations

Apr 2, 2020·International Journal of Molecular Sciences·Giuseppina RoscignoGerolama Condorelli
Jul 4, 2020·Bioscience, Biotechnology, and Biochemistry·Xiaolin WangWenping Zhang
Mar 28, 2020·Journal of Molecular Neuroscience : MN·Mehrdokht MazdehSoudeh Ghafouri-Fard
Aug 23, 2020·Cancers·Didem SakaHande Asimgil
Jan 5, 2021·Frontiers in Bioengineering and Biotechnology·Yuxin RanHongbo Qi
May 11, 2020·Cancer Letters·Samir JanaSharad S Singhal
Mar 8, 2021·Experimental Gerontology·Franco F Roldán Gallardo, Amado A Quintar
Aug 19, 2021·Critical Reviews in Microbiology·Deepansh ModyVibha Rani
Nov 12, 2021·Frontiers in Oncology·Guangbing XiongRenyi Qin

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Datasets Mentioned

BETA
GSE125179

Methods Mentioned

BETA
surgical resection

Software Mentioned

mirDIP
NAViGaTOR
Xena Functional Genomics Explorer
AMP
ToppGene Suite
Affymetrix
Morpheus
Expression Console
edgeR package

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