MicroRNA Profile and Adaptive Response to Exercise Training: A Review

International Journal of Sports Medicine
Daria Domańska-SenderowskaEwa Brzeziańska-Lasota

Abstract

MicroRNAs are small non-coding regulatory RNAs which may be released into the systemic circulation as a consequence of the body's adaptation to exercise. The expression profile of circulating miRNAs (ci-miRNAs) has been proposed as a potential diagnostic biomarker for adaptive responses of particular systems to physical exertion. Several miRNAs are recognized as regulators of signalling pathways such as the IGF1/PI3K/AKT/mTOR axis, relevant to exercise adaptation. MicroRNA levels may fluctuate depending on training type/exercise regimen in correlation with phenotypic features such as VO2 max. Muscle-specific miRNAs have been proposed as regulators of skeletal muscle/myocardial interactions during physical exertion, thereby facilitating adaptation. Differential expression of miRNAs may relate to molecular patterns of communication triggered during/after exercise as response, recovery and adaptation mechanisms to training load. This review highlights recent findings and the potential significance of specific miRNAs in the process of exercise adaptation. Altered ci-miRNA profiles following exercise suggest that they may be useful biomarkers of health and adaptation to intervention strategies. Identification of the concert of miRNA...Continue Reading

Citations

Jan 23, 2020·Journal of Cellular Physiology·Thomas BeiterDirk Moser
Feb 12, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Suzanne DufresneAmélie Rébillard
Aug 11, 2020·American Journal of Physiology. Heart and Circulatory Physiology·Tony G DawkinsRob E Shave
Sep 18, 2020·International Journal of Molecular Sciences·Stefania FochiMaria Grazia Romanelli
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Apr 11, 2021·Npj Regenerative Medicine·Hongyun WangJunjie Xiao
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Jul 3, 2021·International Journal of Molecular Sciences·Johannes BurtscherNadège Zanou
Aug 31, 2021·Journal of Sport and Health Science·Steven D HicksMichael N Dretsch
Nov 19, 2021·Journal of Applied Physiology·Bruno R A PelozinTiago Fernandes

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