MicroRNA profile in the squamous cell carcinoma: prognostic and diagnostic roles

Heliyon
Soudeh Ghafouri-FardZeinab Shirvani Farsani

Abstract

Head and neck squamous cell carcinomas (HNSCCs) are human malignancies associated with both genetic and environmental factors. MicroRNAs (miRNAs) as a group of small non-coding RNAs have prominent roles in the development of this kind of cancer. Expressions of several miRNAs have been demonstrated to be increased in HNSCC samples vs. non-malignant tissues. In silico prediction tools and functional analyses have confirmed the function of some miRNAs in the modulation of cancer-associated targets, thus indicating these miRNAs as onco-miRs. Moreover, numerous miRNAs have been down-regulated in HNSCC samples. Their targets mostly enhance cell proliferation or inhibit apoptosis. miRNAs signature has practical implications in the diagnosis, staging, and management of HNSC. Most notably, numerous miRNAs have been shown to alter response of tumor cells to anti-cancer drugs such as cisplatin and doxorubicin. Circulating levels of these small transcripts have been suggested as promising biomarkers for diagnosis of HNSCC. In the present manuscript, we sum up the available literature regarding the miRNAs signature in HNSCC and their role as diagnostic/prognostic biomarkers.

References

Jun 10, 2005·Nature·Jun LuTodd R Golub
May 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Thian-Sze WongWilliam Ignace Wei
Jan 31, 2009·The American Journal of Pathology·Geoffrey ChildsNicolas F Schlecht
Dec 17, 2010·Nature Reviews. Cancer·C René LeemansRuud H Brakenhoff
May 3, 2011·Current Genomics·Leigh-Ann Macfarlane, Paul R Murphy
Feb 22, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mohammad Aminur RahmanDong M Shin
Apr 12, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Longzhu PiaoQuintin Pan
Feb 6, 2013·Oral Oncology·W S SanthiM Radhakrishna Pillai
Feb 19, 2013·International Journal of Cancer. Journal International Du Cancer·Pinaki BoseJoseph C Dort
Mar 13, 2014·Molecular and Cellular Biochemistry·Wenhao RenKeqian Zhi
Oct 9, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Jin-Feng TangGang Liu
Oct 14, 2014·International Journal of Oncology·Xiyan XiaoYanping Zhang
Nov 5, 2014·Expert Review of Anticancer Therapy·Yaghma MasoodPathmanathan Rajadurai
Dec 3, 2014·Annals of the New York Academy of Sciences·Wenyue Sun, Joseph A Califano
Mar 19, 2015·Oral Diseases·F ZahranC Scully
May 8, 2015·Cancer Biology & Therapy·Bo HouKazuhiko Takeuchi
Jun 10, 2015·British Journal of Cancer·I SummererH Zitzelsberger
Jun 10, 2015·Oncotarget·Berta Victoria MartinezMichal M Masternak
Jul 15, 2015·Archives of Oral Biology·Zonggao ShiM Sharon Stack
Aug 1, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Huanxi XuNing Li
Aug 27, 2015·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Osamu BabaHiroki Bukawa
Oct 23, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lili Wang, Hongchen Liu

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
xenograft
biopsy
transfection
surgical resection

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis