MicroRNA Profile of Cardiovascular Risk in Patients with Obstructive Sleep Apnea.

Respiration; International Review of Thoracic Diseases
Fernando Santamaria-MartosManuel Sánchez-de-la-Torre

Abstract

Obstructive sleep apnea (OSA) is a common disease caused by repeated episodes of collapse of the upper airway during sleep and is associated with the development of cardiovascular disease (CVD). However, there is high heterogeneity in the impact of OSA on patients. Until now, the profile of OSA patients at risk of developing CVD has not been defined, including the measurable variables that could be used to predict the CVD risk of a patient with OSA. The aim of this study was to identify the microRNA (mi-RNA) profile associated with CVD in patients with OSA. This is an observational, cross-sectional study that included 132 male patients. Three groups were defined as OSA patients, OSA patients with hypertension, and OSA patients who developed a major cardiovascular event. Polysomnography and ambulatory blood pressure measurements were performed. The expression profiling of 188 miRNAs in plasma was performed in 21 subjects (matched by BMI and age) by the TaqMan low density array (TLDA). miRNAs differentially expressed in the different subgroups of patients and miRNAs that correlated with the cardiovascular risk SCORE were selected for validation by RT-qPCR in the 111 remaining patients. From the TLDA analysis, 7 miRNAs were select...Continue Reading

Citations

Apr 23, 2021·Environmental Science and Pollution Research International·Jie YuXiaomin Zhang
Jul 25, 2021·International Journal of Molecular Sciences·Edyta DziadkowiakBogusław Paradowski

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