MicroRNA profiling of Sendai virus-infected A549 cells identifies miR-203 as an interferon-inducible regulator of IFIT1/ISG56

Journal of Virology
William A Buggele, Curt M Horvath

Abstract

The mammalian type I interferon (IFN) response is a primary barrier for virus infection and is essential for complete innate and adaptive immunity. Both IFN production and IFN-mediated antiviral signaling are the result of differential cellular gene expression, a process that is tightly controlled at transcriptional and translational levels. To determine the potential for microRNA (miRNA)-mediated regulation of the antiviral response, small-RNA profiling was used to analyze the miRNA content of human A549 cells at steady state and following infection with the Cantell strain of Sendai virus, a potent inducer of IFN and cellular antiviral responses. While the miRNA content of the cells was largely unaltered by infection, specific changes in miRNA abundance were identified during Sendai virus infection. One miRNA, miR-203, was found to accumulate in infected cells and in response to IFN treatment. Results indicate that miR-203 is an IFN-inducible miRNA that can negatively regulate a number of cellular mRNAs, including an IFN-stimulated gene target, IFIT1/ISG56, by destabilizing its mRNA transcript.

References

Aug 30, 2013·Virology Journal·Ole LagatieLieven J Stuyver
Apr 8, 2014·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Ram Savan
Apr 5, 2016·Veterinary and Comparative Oncology·N Terron-CanedoL Nasir
Dec 4, 2014·Cytokine & Growth Factor Reviews·Gianna FiorucciGiovanna Romeo
Apr 8, 2018·BMC Veterinary Research·Miaoli WuPengju Guo
Jan 23, 2018·Journal of Leukocyte Biology·Kei-Ichiro ArimotoDong-Er Zhang
May 4, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Yifan ChenCristan Herbert
Feb 20, 2019·Viruses·Francine AzouzMukesh Kumar
Jul 20, 2018·Frontiers in Immunology·Thi Hiep NguyenMing Yang

Citations

Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
May 10, 2002·Nucleic Acids Research·Tony YuenStuart C Sealfon
Apr 23, 2005·Science·Charles-Henri LecellierOlivier Voinnet
Sep 6, 2005·Science·Catherine L JoplingPeter Sarnow
Feb 18, 2006·Science·Antonio J GiraldezAlexander F Schier
Feb 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ligang WuJoel G Belasco
Aug 4, 2006·Proceedings of the National Academy of Sciences of the United States of America·Konstantin D TaganovDavid Baltimore
Aug 19, 2007·Cell·Shou-Wei Ding, Olivier Voinnet
Oct 19, 2007·Nature·Irene M PedersenMichael David
Mar 29, 2008·Methods in Molecular Biology·Keita MiyoshiMikiko C Siomi
May 10, 2008·Bioinformatics·Pan DuSimon M Lin
Jun 11, 2008·Cell Host & Microbe·Ken J IshiiShizuo Akira
Aug 1, 2008·Nature·Daehyun BaekDavid P Bartel
Aug 1, 2008·Nature·Matthias SelbachNikolaus Rajewsky
Sep 4, 2008·Molecular Systems Biology·David J LynnFiona S L Brinkman
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
Feb 26, 2009·Cell·Richard W Carthew, Erik J Sontheimer
Mar 11, 2009·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Natalia J Martinez, Albertha J M Walhout
May 20, 2009·Genes & Development·Jennifer L Umbach, Bryan R Cullen
Jul 15, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jin HouXuetao Cao
Sep 18, 2009·The Journal of Investigative Dermatology·Enikö SonkolyAndor Pivarcsi
Jan 15, 2010·Journal of Virology·Yu LiMichael G Katze
Jun 18, 2010·Journal of Virology·Liping SongWenlin Huang
Aug 14, 2010·Nature Reviews. Immunology·Shou-Wei Ding
Sep 2, 2010·Proceedings of the National Academy of Sciences of the United States of America·Alina BaumAdolfo García-Sastre
Sep 14, 2010·Journal of Biochemistry·Brandi N Davis-Dusenbery, Akiko Hata
Jan 20, 2011·Nature Reviews. Genetics·Eric Huntzinger, Elisa Izaurralde
Mar 9, 2011·Liver International : Official Journal of the International Association for the Study of the Liver·Magdalena Filipowicz
May 25, 2011·Journal of Biomedical Informatics·Harsh DweepNorbert Gretz
Sep 8, 2011·Genes & Development·Bryan R Cullen

Related Concepts

Tumor Virus Infections
ISG56 protein, human
IFIT1 protein, human
Virus Diseases
Transcription, Genetic
MIRN203 microRNA, human
Human leukocyte interferon
RNA, Small Temporal
Gene Expression
Interferon

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