MicroRNA-regulated gene networks during mammary cell differentiation are associated with breast cancer

Carcinogenesis
Eylem AydoğduCecilia Williams

Abstract

MicroRNAs (miRNAs) play pivotal roles in stem cell biology, differentiation and oncogenesis and are of high interest as potential breast cancer therapeutics. However, their expression and function during normal mammary differentiation and in breast cancer remain to be elucidated. In order to identify which miRNAs are involved in mammary differentiation, we thoroughly investigated miRNA expression during functional differentiation of undifferentiated, stem cell-like, murine mammary cells using two different large-scale approaches followed by qPCR. Significant changes in expression of 21 miRNAs were observed in repeated rounds of mammary cell differentiation. The majority, including the miR-200 family and known tumor suppressor miRNAs, was upregulated during differentiation. Only four miRNAs, including oncomiR miR-17, were downregulated. Pathway analysis indicated complex interactions between regulated miRNA clusters and major pathways involved in differentiation, proliferation and stem cell maintenance. Comparisons with human breast cancer tumors showed the gene profile from the undifferentiated, stem-like stage clustered with that of poor-prognosis breast cancer. A common nominator in these groups was the E2F pathway, which was...Continue Reading

References

Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·T SørlieA L Børresen-Dale
Jun 11, 2004·Cell Cycle·Harry A Rogoff, Timothy F Kowalik
Jun 11, 2004·Cell Cycle·Hans-Guido Wendel, Scott W Lowe
Mar 16, 2005·Cell·Steven M JohnsonFrank J Slack
Jun 10, 2005·Nature·Lin HeScott M Hammond
Jul 1, 2005·Breast Cancer Research : BCR·Goberdhan DimriVimla Band
Sep 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Lance D MillerJonas Bergh
Mar 25, 2006·Nature Reviews. Cancer·Aurora Esquela-Kerscher, Frank J Slack
Oct 25, 2006·Nature Reviews. Cancer·George A Calin, Carlo M Croce
Aug 19, 2007·Cancer Research·Charles D JohnsonFrank J Slack
Sep 19, 2007·Genome Biology·Paul M Krzyzanowski, Miguel A Andrade-Navarro
Dec 15, 2007·Genes & Development·Ingrid IbarraGregory J Hannon
Jul 5, 2008·Expert Review of Molecular Diagnostics·Fernanda MilaneziFernando C Schmitt
Aug 1, 2008·Nature·Daehyun BaekDavid P Bartel
Mar 27, 2009·Molecular Biology of the Cell·David VaughtDana M Brantley-Sieders
Apr 15, 2009·Molecular and Cellular Biology·Kim PedersenJoaquín Arribas
Sep 12, 2009·The EMBO Journal·Chin-Hsing LinRobert N Eisenman
Oct 15, 2009·Science Signaling·Dimitrios IliopoulosPhilip N Tsichlis
Jan 28, 2010·Journal of Cell Science·Stephanie B GreeneJeffrey M Rosen
Jun 24, 2010·Cancer Research·Jason F WigginsAndreas G Bader
Jul 22, 2010·Journal of Cellular Physiology·Chien-Ling HuangChing-Ping Tseng
Jan 5, 2011·Journal of Experimental & Clinical Cancer Research : CR·Jian-guo SunShao-xiang Zhang

❮ Previous
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Citations

Nov 29, 2013·International Journal of Molecular Sciences·Elvira D'Ippolito, Marilena V Iorio
Nov 23, 2013·Cancer Letters·Xiangling FengYaguang Xi
Feb 20, 2015·Molecular Medicine Reports·Xiao-Lu ZhuYin-Cheng Teng
Dec 4, 2015·International Journal of Molecular Sciences·Andrea MatheKelly A Avery-Kiejda
Dec 25, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Lin MaXianzhou Jiang
Aug 25, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Jinqi XueWenhai Zhang
May 31, 2015·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Nastaran Mohammadi Ghahhari, Sadegh Babashah
Jan 27, 2015·American Journal of Obstetrics and Gynecology·Michal A ElovitzAmy G Brown
Mar 10, 2015·Cancer Letters·Xinbing SuiHongming Pan
Jul 27, 2014·Biochemical and Biophysical Research Communications·Sifeng TaoWenjie Yue
Mar 11, 2015·Biochemistry. Biokhimii︠a︡·V I LoginovE A Braga
Jul 19, 2017·International Journal of Molecular Sciences·Duy N DoEveline M Ibeagha-Awemu
Jul 31, 2013·Molecular and Cellular Biology·Tatiana Londoño GentileKathryn E Wellen
Jun 28, 2014·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·M Luisa DóriaLuisa A Helguero
Jul 10, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Qian TangGuotao Tang
Sep 4, 2018·International Journal of Experimental Pathology·Peng ZhangQikang Zhao
May 10, 2019·Journal of Cellular Physiology·Jun WangCecilia Williams
Jun 25, 2020·Cancer Metastasis Reviews·Belinda J Petri, Carolyn M Klinge
Jul 5, 2017·Experimental and Therapeutic Medicine·Ying Chen, Lei Zhang
Jul 13, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mariangela De RobertisVito Michele Fazio
Jun 5, 2020·Seminars in Cancer Biology·Dipta SenguptaSamir Kumar Patra

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