MicroRNA Regulation of Epithelial to Mesenchymal Transition

Journal of Clinical Medicine
Mohammed L AbbaHeike Allgayer

Abstract

Epithelial to mesenchymal transition (EMT) is a central regulatory program that is similar in many aspects to several steps of embryonic morphogenesis. In addition to its physiological role in tissue repair and wound healing, EMT contributes to chemo resistance, metastatic dissemination and fibrosis, amongst others. Classically, the morphological change from epithelial to mesenchymal phenotype is characterized by the appearance or loss of a group of proteins which have come to be recognized as markers of the EMT process. As with all proteins, these molecules are controlled at the transcriptional and translational level by transcription factors and microRNAs, respectively. A group of developmental transcription factors form the backbone of the EMT cascade and a large body of evidence shows that microRNAs are heavily involved in the successful coordination of mesenchymal transformation and vice versa, either by suppressing the expression of different groups of transcription factors, or otherwise acting as their functional mediators in orchestrating EMT. This article dissects the contribution of microRNAs to EMT and analyzes the molecular basis for their roles in this cellular process. Here, we emphasize their interaction with cor...Continue Reading

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Citations

Apr 6, 2016·Cancer Letters·Mohammed L AbbaHeike Allgayer
Oct 23, 2016·Cellular and Molecular Life Sciences : CMLS·Lidong Sun, Jia Fang
Sep 7, 2016·Journal of Experimental & Clinical Cancer Research : CR·Peixin DongNoriaki Sakuragi
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Jul 15, 2021·Molecular Cancer Research : MCR·Dishari GhatakSusanta Roychoudhury

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Methods Mentioned

BETA
transfection
xenograft
nuclear translocation

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