MicroRNA Regulation of Host Immune Responses following Fungal Exposure

Frontiers in Immunology
Tara L CrostonBrett J Green

Abstract

Fungal bioaerosols are ubiquitous in the environment and human exposure can result in a variety of health effects ranging from systemic, subcutaneous, and cutaneous infections to respiratory morbidity including allergy, asthma, and hypersensitivity pneumonitis. Recent research has focused on the role of microRNAs (miRNAs) following fungal exposure and is overlooked, yet important, group of regulators capable of influencing fungal immune responses through a variety of cellular mechanisms. These small non-coding ribose nucleic acids function to regulate gene expression at the post-transcriptional level and have been shown to participate in multiple disease pathways including cancer, heart disease, apoptosis, as well as immune responses to microbial hazards and occupational allergens. Recent animal model studies have characterized miRNAs following the exposure to inflammatory stimuli. Studies focused on microbial exposure, including bacterial infections, as well as exposure to different allergens have shown miRNAs, such as miR-21, miR-146, miR-132, miR-155, and the let-7 family members, to be involved in immune and inflammatory responses. Interestingly, the few studies have assessed that the miRNA profiles following fungal exposur...Continue Reading

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Citations

Feb 19, 2019·Genetics and Molecular Biology·Juliana S de CurcioCélia Maria de Almeida Soares
Mar 21, 2020·Frontiers in Cellular and Infection Microbiology·Aize PellonDavid L Moyes
Aug 7, 2020·Memórias do Instituto Oswaldo Cruz·Junya de Lacorte SingulaniMaria José Soares Mendes-Giannini
Feb 15, 2019·Technology in Cancer Research & Treatment·Yiming MengGuirong Zhang
May 7, 2020·The World Allergy Organization Journal·Luis CaraballoAlexander Karaulov
May 8, 2021·American Journal of Reproductive Immunology : AJRI·Maria Agustina AzpirozGabriela Gutiérrez
May 25, 2021·Frontiers in Physiology·Mian Muhammad AwaisJingchen Sun
May 2, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chenyi YuHailin Zhang

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Methods Mentioned

BETA
bronchoalveolar
lavage
transgenic

Software Mentioned

IPA
Ingenuity Pathway Analysis
Ingenuity Pathway Analysis ( IPA )

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