MicroRNA responses to environmental liver carcinogens: Biological and clinical significance

Clinica Chimica Acta; International Journal of Clinical Chemistry
Vicky Nicolaidou, C Koufaris

Abstract

A large number of biological, chemical, and dietary factors have been implicated in the development of liver cancer. These involve complex and protracted interactions between genetic, epigenetic, and environmental factors. The survival rate for patients diagnosed with late-stage liver cancer is currently low due to the aggressive nature of the disease and resistance to therapy. An increasing body of evidence has offered support for the crucial role of non-coding microRNA (miRNA) in directing hepatic responses to environmental risk factors for liver cancer. In this review we focus on miRNA responses to environmental liver cancer risk factors and their potential biological and clinical significance.

References

Apr 5, 2005·Toxicologic Pathology·Jerry F Hardisty, Amy E Brix
Jan 13, 2006·International Journal of Cancer. Journal International Du Cancer·Donald Maxwell Parkin
May 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Farin KamangarWilliam F Anderson
Aug 23, 2006·Journal of Cellular Biochemistry·Huban KutayKalpana Ghoshal
Aug 25, 2006·Nature Reviews. Cancer·Paraskevi A Farazi, Ronald A DePinho
Aug 19, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Ivy D MoffatAllan B Okey
Oct 30, 2007·Molecular Cell·Eugene BerezikovEric C Lai
Dec 29, 2007·Alcoholism, Clinical and Experimental Research·Yueming TangAli Keshavarzian
Apr 25, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yannick LadeiroJessica Zucman-Rossi
Nov 26, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Onpan CheungArun J Sanyal
Feb 20, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Sean F AltekruseMarsha E Reichman
Mar 20, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Wei-Chih TsaiAnn-Ping Tsou
Jul 28, 2009·Mutation Research·Lya G HernándezJan van Benthem
Aug 28, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Bo WangSamson T Jacob
Oct 28, 2009·Carcinogenesis·Philippe Irigaray, Dominique Belpomme
Dec 5, 2009·World Journal of Gastroenterology : WJG·Shashi BalaGyongyi Szabo
Dec 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Pascal PineauAnne Dejean
Dec 31, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elisa FabbriniSamuel Klein
Jan 23, 2010·Nature Reviews. Molecular Cell Biology·Richard J JacksonTatyana V Pestova
Feb 23, 2010·Environmental Health Perspectives·Yan Liu, Felicia Wu
Feb 27, 2010·Journal of Hepatology·Christine NeuveutMarie Annick Buendia
Jun 26, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jinfeng HuangShuhan Sun
Jul 17, 2010·Biochemical and Biophysical Research Communications·Lipeng QiuSongdong Meng
Oct 23, 2010·Molecular Cell·Anthony K L Leung, Phillip A Sharp
Nov 3, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Chunxian ZengShi-Mei Zhuang
Dec 24, 2010·Journal of Experimental & Clinical Cancer Research : CR·Ren LiKefeng Dou

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Citations

Mar 8, 2016·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Zhaowei ZhangPeiwu Li
May 21, 2016·Journal of Translational Medicine·Lyudmila F Gulyaeva, Nicolay E Kushlinskiy
Nov 3, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Kevin Ita
Aug 11, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Pravin ShendeR S Gaud
May 19, 2020·Toxicology and Industrial Health·Vicky Nicolaidou, Costas Koufaris
Jan 21, 2017·Oncology Letters·Chengyong LiuHaibin Huang
Jun 22, 2021·Frontiers in Oncology·Costas Koufaris, Antonis Kirmizis

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