MicroRNA signature of central nervous system-infiltrating dendritic cells in an animal model of multiple sclerosis

Immunology
Mariah L HoyeGregory F Wu

Abstract

Innate immune cells are integral to the pathogenesis of several diseases of the central nervous system (CNS), including multiple sclerosis (MS). Dendritic cells (DCs) are potent CD11c+ antigen-presenting cells that are critical regulators of adaptive immune responses, particularly in autoimmune diseases such as MS. The regulation of DC function in both the periphery and CNS compartment has not been fully elucidated. One limitation to studying the role of CD11c+ DCs in the CNS is that microglia can upregulate CD11c during inflammation, making it challenging to distinguish bone marrow-derived DCs (BMDCs) from microglia. Selective expression of microRNAs (miRNAs) has been shown to distinguish populations of innate cells and regulate their function within the CNS during neuro-inflammation. Using the experimental autoimmune encephalomyelitis (EAE) murine model of MS, we characterized the expression of miRNAs in CD11c+ cells using a non-biased murine array. Several miRNAs, including miR-31, were enriched in CD11c+ cells within the CNS during EAE, but not LysM+ microglia. Moreover, to distinguish CD11c+ DCs from microglia that upregulate CD11c, we generated bone marrow chimeras and found that miR-31 expression was specific to BMDCs. I...Continue Reading

References

May 5, 1997·FEBS Letters·M OkabeY Nishimune
Jan 6, 2000·Transgenic Research·B E ClausenI Förster
Jun 24, 2004·Nature Reviews. Genetics·Lin He, Gregory J Hannon
Nov 16, 2004·Nature Immunology·Randall L LindquistMichel C Nussenzweig
Mar 1, 2005·Nature Medicine·Eileen J McMahonStephen D Miller
Jun 17, 2005·Journal of Neuroscience Research·Eugene D PonomarevBonnie N Dittel
Mar 3, 2006·The New England Journal of Medicine·Elliot M FrohmanCedric S Raine
Jun 15, 2006·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Burkhard BecherMelanie Greter
May 10, 2007·Current Neurology and Neuroscience Reports·Gregory F Wu, Terri M Laufer
Jun 27, 2007·The Journal of Experimental Medicine·Michele L CatonBoris Reizis
May 21, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Pooja JainBritta Engelhardt
Jul 20, 2010·Biochimica Et Biophysica Acta·Emily M L ChastainStephen D Miller
Mar 29, 2011·Neurologic Clinics·Gregory F Wu, Enrique Alvarez
Jun 2, 2011·Molecular Cancer Research : MCR·Xiaohua LiFan Daiming
Jul 27, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gopal MurugaiyanHoward L Weiner
Aug 9, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Divya SagarPooja Jain
Dec 21, 2012·Annals of the Rheumatic Diseases·Edward K L ChanMinoru Satoh
Jun 19, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Angela S ArchambaultGregory F Wu
Jul 3, 2013·Annals of Neurology·Craig S MooreJack P Antel
Jul 11, 2013·Clinical & Developmental Immunology·Tobias Goldmann, Marco Prinz
Jul 16, 2013·Journal of Autoimmunity·Manu Rangachari, Vijay K Kuchroo
Dec 10, 2013·Nature Neuroscience·Oleg ButovskyHoward L Weiner
Sep 23, 2014·Immunology·Lesley A SmythGiovanna Lombardi
Feb 18, 2016·EMBO Reports·Olivier E PardoJustin Stebbing
Apr 2, 2016·Seminars in Immunology·Tyler K UllandMarco Colonna
Apr 12, 2016·European Journal of Immunology·Johannes OrthgiessJens Eilers
Apr 29, 2016·Nature Reviews. Immunology·Arnav Mehta, David Baltimore
Apr 19, 2017·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mariah L HoyeTimothy M Miller
Jun 24, 2017·Nature Communications·Mariola Kurowska-StolarskaIain B McInnes

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Citations

Jan 23, 2020·International Journal of Molecular Sciences·Seung Ro HanSeung-Hoon Lee
Dec 14, 2018·International Journal of Molecular Sciences·Shivaprasad H VenkateshaKamal D Moudgil
Jun 20, 2020·International Reviews of Immunology·Naeim EhteshamMohammadreza Sharifi
Apr 20, 2019·Frontiers in Immunology·Asma Hassani, Gulfaraz Khan
Feb 6, 2020·Journal of Central Nervous System Disease·Eiman Ma Mohammed
Oct 8, 2020·Journal of Neurochemistry·Deepak Kumar Kaushik, Voon Wee Yong
Feb 20, 2021·Current Opinion in Immunology·Andreia BarrosoFrancisco J Quintana

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