MicroRNA Signatures and Molecular Subtypes of Glioblastoma: The Role of Extracellular Transfer

Stem Cell Reports
Jakub GodlewskiAgnieszka Bronisz

Abstract

Despite the importance of molecular subtype classification of glioblastoma (GBM), the extent of extracellular vesicle (EV)-driven molecular and phenotypic reprogramming remains poorly understood. To reveal complex subpopulation dynamics within the heterogeneous intratumoral ecosystem, we characterized microRNA expression and secretion in phenotypically diverse subpopulations of patient-derived GBM stem-like cells (GSCs). As EVs and microRNAs convey information that rearranges the molecular landscape in a cell type-specific manner, we argue that intratumoral exchange of microRNA augments the heterogeneity of GSC that is reflected in highly heterogeneous profile of microRNA expression in GBM subtypes.

Citations

Mar 14, 2018·Science Advances·Franz L RicklefsE Antonio Chiocca
May 12, 2018·Science·Ralph B PuchalskiGreg D Foltz
Apr 29, 2018·Journal of Neuro-oncology·Elie DiamandisDieter Henrik Heiland
Oct 28, 2018·Radiology and Oncology·Barbara BreznikTamara T Lah
Feb 23, 2019·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Deborah RotoliPablo Martín-Vasallo
Jul 27, 2018·Journal of Molecular Histology·Barbara BreznikCornelis J F Van Noorden
Nov 6, 2018·International Journal of Oncology·Xuejun DaiRuisheng Lin
Mar 22, 2019·Frontiers in Oncology·Delphine GarnierClaire Pecqueur
Mar 1, 2019·Non-coding RNA·Jakub GodlewskiElzbieta Salinska
Aug 18, 2020·Oncogene·Quentin SabbaghJulie Gavard
Jan 20, 2019·Journal of Experimental & Clinical Cancer Research : CR·Xueran ChenZhiyou Fang
Apr 13, 2019·Annual Review of Genomics and Human Genetics·Michael W Graner
Feb 11, 2020·Frontiers in Immunology·Anuroop YekulaLeonora Balaj
Jan 14, 2018·Molecular Cancer Research : MCR·Dieter Henrik HeilandOliver Schnell
Apr 18, 2020·Seminars in Cancer Biology·Faheem Hyder PottooFirdos Alam Khan
Jan 22, 2020·Neurología : publicación oficial de la Sociedad Española de Neurología·L J Reséndiz-CastilloA A Canales-Aguirre
Mar 9, 2021·Signal Transduction and Targeted Therapy·Chaoyue SuLiwu Fu
Apr 4, 2021·Cancers·Jakub GodlewskiAgnieszka Bronisz

❮ Previous
Next ❯

Methods Mentioned

BETA
xenografts
xenograft
transfection

Software Mentioned

Maverix
Arraystar

Related Concepts

Related Feeds

Cancer Stem Cells in Glioblastoma

Glioblastoma is the most common and aggressive type of brain tumor. It contains a population of tumor initiating stem cell-like cells known as cancer stem cells. Investigations are ongoing into these cancer stem cells found in these solid tumors which are highly resistance to treatment. Here is the latest research on cancer stem cells in glioblastoma.