MicroRNA‑181 exerts an inhibitory role during renal fibrosis by targeting early growth response factor‑1 and attenuating the expression of profibrotic markers

Molecular Medicine Reports
Xiaoyan ZhangCongxiu Miao

Abstract

Progressive renal fibrosis is a common complication of chronic kidney disease that results in end‑stage renal disorder. It is well established that several microRNAs (miRs) function as critical regulators implicated in fibrotic diseases. However, the role of miR‑181 in the development and progression of renal fibrosis remains unclear, and the precise mechanism has not yet been fully defined. The present study identified the functional implications of miR‑181 expression during renal fibrosis. miR‑181 exhibited significantly reduced expression in the serum of renal fibrosis patients and in the kidneys of mice with unilateral ureteral obstruction (UUO). In addition, miR‑181 downregulated the expression of human α‑smooth muscle actin (α‑SMA) in response to angiotensin II stimulation. Transfection with miR‑181 mimics significantly suppressed the expression levels of α‑SMA, connective tissue growth factor, collagen type I α1 (COL1A1) and collagen type III α1 (COL3A1) in NRK49F cells. Notably, early growth response factor‑1 (Egr1) was identified as a direct target gene of miR‑181. Furthermore, in vivo experiments revealed that treatment with miR‑181 agonist strongly rescued kidney impairment induced by UUO, as supported by Masson's tr...Continue Reading

References

Nov 13, 1998·The New England Journal of Medicine·G Remuzzi, T Bertani
Mar 10, 2000·American Journal of Physiology. Heart and Circulatory Physiology·N SaadaneL E Chalifour
Jan 6, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·G A MüllerF Strutz
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Apr 10, 2004·Current Opinion in Nephrology and Hypertension·Masayuki Iwano, Eric G Neilson
Jul 13, 2005·Cell·Carlo M Croce, George A Calin
Nov 29, 2005·Science·Xantha Karp, Victor Ambros
Dec 14, 2005·Alcoholism, Clinical and Experimental Research·M T Pritchard, L E Nagy
Mar 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Mitsuo KatoRama Natarajan
Jun 26, 2007·Cells, Tissues, Organs·Jiri ZavadilRobert J Schneider
Apr 25, 2008·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yannick LadeiroJessica Zucman-Rossi
Dec 18, 2008·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Björn FriedrichDorothea Alexander
May 21, 2009·Nature Reviews. Nephrology·Eswari Vilayur, David C H Harris
Sep 15, 2010·Nature Reviews. Nephrology·Peter BoorJürgen Floege
Sep 25, 2010·Journal of the American Society of Nephrology : JASN·Michael Zeisberg, Eric G Neilson
Nov 4, 2010·The International Journal of Biochemistry & Cell Biology·Lynne A MurrayErica L Herzog
Mar 9, 2011·Laboratory Investigation; a Journal of Technical Methods and Pathology·Z I LiHui Y Lan
Mar 23, 2011·Nature Reviews. Nephrology·Johan M LorenzenThomas Thum
Jul 2, 2011·Journal of the American Society of Nephrology : JASN·Xue-Yuan BaiXiang-Mei Chen
Dec 5, 2012·Molecular Therapy : the Journal of the American Society of Gene Therapy·Arthur C K ChungHui Y Lan
Jan 15, 2013·Vascular Pharmacology·Mandeep Kumar Arora, Umesh Kumar Singh
Jun 4, 2013·Lancet·Vivekanand JhaChih-Wei Yang
Jul 19, 2013·The Journal of Clinical Investigation·Marie-Justine GuerquinDelphine Duprez
Nov 20, 2013·Current Opinion in Nephrology and Hypertension·Aaron McClellandPhillip Kantharidis
May 24, 2014·Journal of the American Society of Nephrology : JASN·Johan M LorenzenThomas Thum
Jul 9, 2014·Nature Reviews. Nephrology·Mitsuo Kato, Rama Natarajan
Apr 17, 2015·Annals of the New York Academy of Sciences·Mitsuo Kato, Rama Natarajan
Jul 15, 2015·Experimental Cell Research·Xiujuan LiuXiangmei Chen
Aug 28, 2015·Kidney International Supplements·Daniela MacconiAriela Benigni
Jun 10, 2016·International Journal of Medical Sciences·Hung-Yu ChienWan-Chun Li

❮ Previous
Next ❯

Citations

Mar 4, 2020·International Journal of Molecular Sciences·Emmanuelle Havis, Delphine Duprez
Apr 26, 2019·International Journal of Molecular Sciences·Cynthia Van der HauwaertChristelle Cauffiez
Oct 22, 2021·Frontiers in Nutrition·Daniela GabbiaSara De Martin

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.