microRNA‑181a‑5p functions as an oncogene in renal cell carcinoma.

Molecular Medicine Reports
Yulin LaiLiangchao Ni


Renal cell carcinoma (RCC) is one of the most common urinary tumors. Previous studies have demonstrated that microRNA (miR)‑181a‑5p has an important role in numerous types of cancer. However, the function of miR‑181a‑5p in RCC remains unknown. In the present study, the expression levels of miR‑181a‑5p in RCC tissues and cell lines were investigated using reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR) analysis. The results of the RT‑qPCR analyses suggested that the expression of miR‑181a‑5p was upregulated in RCC tissues and cells lines compared with adjacent normal renal tissues and normal renal cell lines. Furthermore, the effect of miR‑181a‑5p on cell proliferation, migration, invasion and apoptosis was investigated in the present study. Overexpression of miR‑181a‑5p was revealed to suppress the apoptosis of 786‑O and ACHN cells, in addition to enhancing the proliferation, migration and invasion abilities of 786‑O and ACHN cells in vitro, thus suggesting that miR‑181a‑5p may function as an oncogene in RCC. However, further studies are required to investigate the underlying mechanism of miR‑181a‑5p and its potential role as a biomarker for early detection and prognosis, in addition to as a therapeutic t...Continue Reading


Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Feb 26, 2009·Cell·Olivier Voinnet
Mar 7, 2009·The American Journal of Pathology·Rosa Visone, Carlo M Croce
Jul 28, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Gang ChenRong-Ping Zhou
Aug 16, 2014·Experimental Biology and Medicine·Raimundo Fernandes de Araújo JúniorAurigena Antunes de Araújo
Oct 9, 2016·Biochemical and Biophysical Research Communications·Fei LiuZhengyue Pan
Dec 21, 2016·Molecular Cancer·Klaudia K BrodaczewskaAnna M Czarnecka
Mar 2, 2017·The Journal of Clinical Investigation·Brian D AdamsFrank J Slack
Mar 10, 2017·Nature Reviews. Disease Primers·James J HsiehVincenzo Ficarra
Jan 1, 2015·Journal of Kidney Cancer and VHL·Gianluca Aguiari
Apr 7, 2017·Journal of the National Cancer Institute·Stefan B EichmüllerBarbara Seliger

Related Concepts

miR-181d, human
Chromophobe Renal Cell Carcinoma
Cell Motility
Malignant Neoplasm of Kidney
Gene Expression Regulation, Neoplastic
Apoptosis, Intrinsic Pathway
MRNA Differential Display
RNA, Small Temporal

Related Feeds


Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Related Papers

Cancer Biomarkers : Section a of Disease Markers
Paul Cairns
International Journal of Urology : Official Journal of the Japanese Urological Association
Yasuyuki KojimaHiroshi Mori
© 2021 Meta ULC. All rights reserved