MicroRNA‑195 inhibits cell proliferation, migration and invasion by targeting defective in cullin neddylation 1 domain containing 1 in cervical cancer.

International Journal of Molecular Medicine
Jinyan ZhongShoufang Kong

Abstract

MicroRNAs (miRs), a class of small non‑coding RNAs, have been demonstrated to perform promoting or suppressive roles in various types of human malignancy. Deregulation of miR‑195 has been observed in numerous types of human cancer, including cervical cancer; however, the detailed molecular mechanism of miR‑195 underlying the malignant progression of cervical cancer remains largely unclear. In the present study, miR‑195 was significantly downregulated in cervical cancer tissue samples compared with adjacent non‑tumor tissue samples, and the reduced expression level of miR‑195 was associated with node metastasis and an advanced clinical stage in cervical cancer. Furthermore, the patients with low miR‑195 expression levels demonstrated shorter survival times when compared with those with high miR‑195 expression levels. In vitro experiments indicated that miR‑195 exerted suppressive effects on the proliferation, migration and invasion of cervical cancer cells. Luciferase reporter gene assay identified defective in cullin neddylation 1 domain containing 1 (DCUN1D1) as a novel target gene of miR‑195 and the expression level of DCUN1D1 was identified to be negatively regulated by miR‑195 in cervical cancer cells. DCUN1D1 was significa...Continue Reading

Citations

Mar 18, 2020·Cancers·Adewale Oluwaseun FadakaAshwil Klein
Feb 16, 2020·Journal of Clinical Laboratory Analysis·Yan Zhang, Hongjie Xu
Jan 25, 2020·International Journal of Genomics·Lei LiBiyun Qian

❮ Previous
Next ❯

Methods Mentioned

BETA
surgical resection
transfection
Protein Assay
Assay
nuclear
neddylation

Software Mentioned

miRDB
Pro Plus
SPSS
TargetScan
Image
DIANAmT

Related Concepts

Related Feeds

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.