MicroRNA‑451 inhibits neuroblastoma proliferation, invasion and migration by targeting macrophage migration inhibitory factor

Molecular Medicine Reports
Geng LiuDingjun Hao

Abstract

Neuroblastoma (NB) is the most prevalent type of extracranial solid tumour in young children. To improve current understanding of the mechanisms, which modulate cancer cell proliferation, invasion and migration, investigations have focused on microRNAs (miRs), a class of small non‑coding RNAs, which post‑transcriptionally regulate gene expression during various crucial cell processes. The present study aimed to investigate the role of miR‑451 in NB. Human NB tissue and adjacent normal tissue were surgically removed, and the expression of miR‑451, and development and pathological characteristics of NB were investigated. The expression of miR‑451 was reduced in the NB tissue, compared with that in the adjacent tissue, and correlations between the reduction in miR‑451 and unfavourable variables included tumour size (P=0.0081), differentiation (P=0.0217), lymph node metastasis (P=0.0489), tumour‑node‑metastasis stage (0.0220) and distant metastases (P=0.0201). Transfection of the SK‑N‑SH and GI‑LA‑N NB cell lines with miR‑451 inhibited cell growth, invasion and migration. Furthermore, the present study demonstrated that macrophage migration inhibitory factor (MIF) was regulated directly by miR‑451 and was a critical mediator of the...Continue Reading

References

Sep 17, 2004·Nature·Victor Ambros
Nov 26, 2005·Science·Kyle Kai-How FarhDavid P Bartel
Jun 26, 2007·Lancet·John M MarisSusan L Cohn
Nov 28, 2007·Virchows Archiv : an International Journal of Pathology·Stefanie SassenCarlos Caldas
Mar 26, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eva BandresJesus Garcia-Foncillas
Feb 12, 2010·Cancer Biology & Therapy·Jigang GuoChen-Yu Zhang
Sep 2, 2010·QJM : Monthly Journal of the Association of Physicians·H ConroyS C Donnelly
Mar 8, 2013·PloS One·Jingbo QiaoDai H Chung
May 25, 2013·Nature Reviews. Cancer·Nai-Kong V Cheung, Michael A Dyer
Nov 26, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Faruk TasDerya Duranyildiz
Jan 22, 2014·Cancer Epidemiology·Dong LiuHuiping Chen
May 21, 2014·International Journal of Oncology·Xuemin LiuJianhua Shi
Jul 12, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yu LiYong-Ming Li
Jul 3, 2015·Molecular Medicine Reports·Dongju ZhaoTaixin Shi

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Citations

Feb 2, 2017·Journal of Cellular Physiology·Sharareh GholaminAmir Avan
May 30, 2019·Journal of Cellular Physiology·Monireh KhordadmehrBehzad Baradaran
Jul 26, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Zhiping Li, Huijun Chen
May 12, 2018·International Journal of Molecular Medicine·Igor BryukhovetskiyYuri Khotimchenko
May 26, 2017·Biomedicines·Nicholas L DentonTimothy P Cripe
Apr 23, 2020·Frontiers in Cell and Developmental Biology·Vivian M LeeMaria Elena de Bellard
Mar 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eugenio CavalliMaria Sofia Basile
Dec 19, 2019·Cancer Metastasis Reviews·Karina Bezerra SalomãoMaría Sol Brassesco
Mar 16, 2021·Frontiers in Oncology·Omidvar RezaeiSoudeh Ghafouri-Fard

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