Abstract
Neuroblastoma (NB) is the most prevalent type of extracranial solid tumour in young children. To improve current understanding of the mechanisms, which modulate cancer cell proliferation, invasion and migration, investigations have focused on microRNAs (miRs), a class of small non‑coding RNAs, which post‑transcriptionally regulate gene expression during various crucial cell processes. The present study aimed to investigate the role of miR‑451 in NB. Human NB tissue and adjacent normal tissue were surgically removed, and the expression of miR‑451, and development and pathological characteristics of NB were investigated. The expression of miR‑451 was reduced in the NB tissue, compared with that in the adjacent tissue, and correlations between the reduction in miR‑451 and unfavourable variables included tumour size (P=0.0081), differentiation (P=0.0217), lymph node metastasis (P=0.0489), tumour‑node‑metastasis stage (0.0220) and distant metastases (P=0.0201). Transfection of the SK‑N‑SH and GI‑LA‑N NB cell lines with miR‑451 inhibited cell growth, invasion and migration. Furthermore, the present study demonstrated that macrophage migration inhibitory factor (MIF) was regulated directly by miR‑451 and was a critical mediator of the...Continue Reading
References
Jan 28, 2004·Cell·David P Bartel
Apr 6, 2004·Oncogene·Yi RenPaul Kwong Hang Tam
Sep 17, 2004·Nature·Victor Ambros
Nov 26, 2005·Science·Kyle Kai-How FarhDavid P Bartel
Feb 2, 2006·Oncogene·Y RenP K H Tam
Mar 23, 2007·Immunity·Richard Bucala, Seamas C Donnelly
Jun 26, 2007·Lancet·John M MarisSusan L Cohn
Nov 28, 2007·Virchows Archiv : an International Journal of Pathology·Stefanie SassenCarlos Caldas
Mar 26, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eva BandresJesus Garcia-Foncillas
Mar 27, 2009·BioFactors·Gordon CookeSeamas C Donnelly
Feb 12, 2010·Cancer Biology & Therapy·Jigang GuoChen-Yu Zhang
Aug 31, 2010·Oncogene·W K K WuJ J Y Sung
Sep 2, 2010·QJM : Monthly Journal of the Association of Physicians·H ConroyS C Donnelly
Mar 8, 2013·PloS One·Jingbo QiaoDai H Chung
Mar 26, 2013·Cancer Cell International·Yubiao GuoDujuan Wang
May 25, 2013·Nature Reviews. Cancer·Nai-Kong V Cheung, Michael A Dyer
Oct 22, 2013·Molecular Cancer·Na LiuJun Ma
Oct 22, 2013·FEBS Letters·Xin ChenQian Dong
Nov 26, 2013·Oncotarget·Dan LiQiangsong Tong
Nov 26, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Faruk TasDerya Duranyildiz
Dec 25, 2013·Oncology Reports·Dong WangXiao-Hui Huang
Jan 8, 2014·International Journal of Medical Sciences·Xiao-Juan PeiQing-Xu Yang
Jan 22, 2014·Cancer Epidemiology·Dong LiuHuiping Chen
Apr 9, 2014·Journal of Translational Medicine·Langping TanRufu Chen
Apr 22, 2014·The Journal of Nutritional Biochemistry·Yoo-Sun KimYuri Kim
May 21, 2014·International Journal of Oncology·Xuemin LiuJianhua Shi
Jun 3, 2014·PloS One·Katherine T MorrisEllen J Beswick
Jun 19, 2014·Oncology Reports·Vincent RichardSven Saussez
Jun 28, 2014·Oncology Reports·Guixiang LvXiaofei Zheng
Jul 12, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yu LiYong-Ming Li
Aug 30, 2014·BMC Cancer·Camila S OliveiraRick F Thorne
Jun 16, 2015·FEBS Letters·Kai WuZonghai Huang
Jul 3, 2015·Molecular Medicine Reports·Dongju ZhaoTaixin Shi
Aug 19, 2015·Neoplasma·Y WangZ DU
Citations
Dec 7, 2016·Reproductive Sciences·Warren B NothnickAmanda Graham
Feb 2, 2017·Journal of Cellular Physiology·Sharareh GholaminAmir Avan
Jan 10, 2018·Cancer Cell International·Yongbo YuXin Ni
Jan 27, 2018·The International Journal of Neuropsychopharmacology·Xiao WangJan Sundquist
May 30, 2019·Journal of Cellular Physiology·Monireh KhordadmehrBehzad Baradaran
Jul 26, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Zhiping Li, Huijun Chen
May 12, 2018·International Journal of Molecular Medicine·Igor BryukhovetskiyYuri Khotimchenko
May 26, 2017·Biomedicines·Nicholas L DentonTimothy P Cripe
Jul 3, 2018·Oncology Letters·Wei WuZhibao Lv
Apr 23, 2020·Frontiers in Cell and Developmental Biology·Vivian M LeeMaria Elena de Bellard
Aug 7, 2017·Experimental and Therapeutic Medicine·Yue ZhaoLina Li
Mar 12, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Eugenio CavalliMaria Sofia Basile
Dec 19, 2019·Cancer Metastasis Reviews·Karina Bezerra SalomãoMaría Sol Brassesco
Mar 16, 2021·Frontiers in Oncology·Omidvar RezaeiSoudeh Ghafouri-Fard
Mar 23, 2021·Drug Discovery Today·Angelina OsipyanFrank J Dekker
Jan 14, 2017·Oncology Research·Hui ZhouKun Xia