MicroRNA‑874 inhibits proliferation and invasion of pancreatic ductal adenocarcinoma cells by directly targeting paired box 6

Molecular Medicine Reports
Jiandong DiaoYanling Liu

Abstract

Studies have demonstrated that a number of microRNAs (miRNAs) are dysregulated in pancreatic ductal adenocarcinoma (PDAC), and alterations in their expression may affect the onset and progression of PDAC. Therefore, the expression patterns, biological functions and associated molecular mechanisms of miRNAs in PDAC should be elucidated for the development of novel therapeutic methods. Previous studies reported significant miRNA‑874 (miR‑874) dysregulation in multiple types of human cancer. However, the expression pattern, possible roles and underlying mechanisms of miR‑874 in PDAC remain to be elucidated. This study evaluated miR‑874 expression in PDAC and examined its biological functions and underlying mechanism of action in PDAC progression. miR‑874 expression was downregulated in PDAC tissues and cell lines. Functional experiments demonstrated that upregulation of miR‑874 inhibited cell proliferation and invasion in PDAC. Additionally, paired box 6 (PAX6) was predicted as a putative target of miR‑874 using bioinformatics analysis. Further experiments demonstrated that PAX6 may be the direct target gene of miR‑874 in PDAC. PAX6 knockdown exhibited similar inhibitory effects to miR‑874 overexpression in PDAC cells. In addition...Continue Reading

References

Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Oct 17, 2003·Pediatric Research·Isabel M Hanson
Feb 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·George Adrian CalinCarlo M Croce
May 4, 2005·Cancer Research·Richard I Gregory, Ramin Shiekhattar
Jul 13, 2005·Cell·Carlo M Croce, George A Calin
May 31, 2007·Proceedings of the National Academy of Sciences of the United States of America·J Robin LytleJoan A Steitz
Mar 16, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Sadegh Babashah, Masoud Soleimani
May 3, 2011·Genes & Cancer·Brandi N Davis-Dusenbery, Akiko Hata
May 4, 2011·Developmental Neurobiology·Petrina A GeorgalaDavid J Price
Apr 16, 2013·Biochemical and Biophysical Research Communications·Divya KesanakurtiChandramu Chetty
Sep 11, 2014·The New England Journal of Medicine·David P RyanNabeel Bardeesy
Sep 30, 2014·Cancer Epidemiology·Matthew D BurkeyFabian M Johnston
Oct 14, 2014·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·J MoirD M Manas
Jan 7, 2015·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
May 23, 2015·Nature Reviews. Cancer·Shuibin Lin, Richard I Gregory
Dec 4, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Dong DongGuishan Gu
Jul 30, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xiaohua LiRui Wang
Feb 12, 2017·Carcinogenesis·Shinichi KannoHiroshi Nakase
May 27, 2017·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Eva KaramitopoulouErik Vassella
Aug 16, 2017·Experimental and Therapeutic Medicine·Qiongyan ZouDewu Zhong
Nov 8, 2017·The Journal of Biological Chemistry·Tanushree GhoshSandeep Saxena

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Mar 7, 2021·Biology·Martina GiuppiMichele Ghidini

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