MicroRNA‑874 prohibits the proliferation and invasion of retinoblastoma cells by directly targeting metadherin

Molecular Medicine Reports
Yongfeng ZhangYuehua Zhao

Abstract

MicroRNAs (miRNAs/miRs) serve important roles in regulating gene expression by directly binding to the 3'‑untranslated regions of target genes. Multiple miRNAs are dysregulated in retinoblastoma (RB) and their dysregulation is closely related to RB malignancy. Therefore, exploring the detailed roles of miRNAs in RB is valuable to facilitate the development of effective therapeutic targets for patients with this disease. miRNA‑874‑3p (miR‑874) has been recently reported to be downregulated in several types of human cancer and serves an essential role in cancer progression. However, the expression pattern and detailed roles of miR‑874 in RB, as well as the underlying molecular mechanisms in RB, have not been clearly elucidated. Therefore, this study detected miR‑874 expression in RB tissues and cell lines. The biological roles of miR‑874 in RB were determined and the underlying mechanisms of its actions in RB cells were also examined. This study revealed that miR‑874 expression was aberrantly underexpressed in RB tissues and cell lines. However, returning miR‑874 expression restricted the proliferative and invasive abilities of RB cells. In terms of the underlying mechanism, metadherin (MTDH) was validated as a direct target gene...Continue Reading

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Oct 24, 2018·Journal of Cancer Research and Clinical Oncology·Lara Elis Alberici DelsinMaria Sol Brassesco
Jun 20, 2020·Endocrine, Metabolic & Immune Disorders Drug Targets·Sarubala MalayaperumalSurajit Pathak

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