MicroRNAs 146a/b-5 and 425-3p and 24-3p are markers of antidepressant response and regulate MAPK/Wnt-system genes

Nature Communications
Juan Pablo LopezGustavo Turecki

Abstract

Antidepressants (ADs) are the most common treatment for major depressive disorder (MDD). However, only ∼30% of patients experience adequate response after a single AD trial, and this variability remains poorly understood. Here, we investigated microRNAs (miRNAs) as biomarkers of AD response using small RNA-sequencing in paired samples from MDD patients enrolled in a large, randomized placebo-controlled trial of duloxetine collected before and 8 weeks after treatment. Our results revealed differential expression of miR-146a-5p, miR-146b-5p, miR-425-3p and miR-24-3p according to treatment response. These results were replicated in two independent clinical trials of MDD, a well-characterized animal model of depression, and post-mortem human brains. Furthermore, using a combination of bioinformatics, mRNA studies and functional in vitro experiments, we showed significant dysregulation of genes involved in MAPK/Wnt signalling pathways. Together, our results indicate that these miRNAs are consistent markers of treatment response and regulators of the MAPK/Wnt systems.

References

Jun 5, 2002·Genome Research·W James KentDavid Haussler
Jun 24, 2004·Nature Reviews. Genetics·Lin He, Gregory J Hannon
Jan 24, 2006·Nature Reviews. Neuroscience·Olivier Berton, Eric J Nestler
Apr 21, 2006·Medical Care·Jessica S Banthin, G Edward Miller
Apr 25, 2006·Biological Psychiatry·Cortney A TurnerSimon J Evans
Jul 18, 2006·Nucleic Acids Research·Jan Krüger, Marc Rehmsmeier
Sep 17, 2008·Research in Social & Administrative Pharmacy : RSAP·Yan ChenNick C Patel
Jan 10, 2009·Nature Protocols·Da Wei HuangRichard A Lempicki
Mar 3, 2009·The British Journal of Psychiatry : the Journal of Mental Science·Rudolf UherPeter McGuffin
Jul 31, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Nader PerroudIan Craig
Nov 3, 2010·Nucleic Acids Research·Ana Kozomara, Sam Griffiths-Jones
Jul 30, 2011·Nature Protocols·Sam A GoldenScott J Russo
Aug 5, 2011·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Heath D SchmidtRonald S Duman
Sep 13, 2011·Neuropharmacology·Ronald S DumanGeorge Aghajanian
Nov 19, 2011·Nature Reviews. Genetics·Manel Esteller
Dec 1, 2011·Statistical Methods in Medical Research·Jun Li, Robert Tibshirani
May 2, 2012·Molecular Psychiatry·J P LopezG Turecki
May 16, 2012·Cellular and Molecular Life Sciences : CMLS·Vanja Duric, Ronald S Duman
Jun 12, 2012·Current Pharmaceutical Design·Sidney H KennedyClaudio Soares
Jul 21, 2012·Nature Reviews. Neuroscience·Irfan A Qureshi, Mark F Mehler
Jan 1, 2011·Translational Psychiatry·J M LaunayO Kellermann
Oct 10, 2012·Bioinformatics·Chong-Jian ChenEmmanuel Barillot
Feb 7, 2013·BMC Medicine·Nilay HepgulCarmine M Pariante
May 18, 2013·Nucleic Acids Research·Maria D ParaskevopoulouA G Hatzigeorgiou
Nov 28, 2013·Nucleic Acids Research·Ana Kozomara, Sam Griffiths-Jones
Nov 8, 2014·Nucleic Acids Research·Nathan Wong, Xiaowei Wang
Nov 11, 2014·Nature·Caroline DiasEric J Nestler
Dec 17, 2014·Molecular Psychiatry·M Peciña, J-K Zubieta
Dec 18, 2014·Genome Biology·Michael I LoveSimon Anders
May 16, 2015·Nucleic Acids Research·Ioannis S VlachosArtemis G Hatzigeorgiou
Jun 24, 2015·Molecular Psychiatry·R JansenP F Sullivan
Aug 1, 2015·Nature Methods·Harsh Dweep, Norbert Gretz
Aug 13, 2015·ELife·Vikram AgarwalDavid P Bartel

❮ Previous
Next ❯

Citations

Dec 14, 2017·Journal of Cellular Biochemistry·Jahanshir TavakolizadehHamed Mirzaei
Dec 28, 2017·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Sidney H Kennedy, Amanda K Ceniti
Apr 28, 2018·Expert Review of Molecular Diagnostics·Cristina MoraAnnamaria Cattaneo
Nov 20, 2019·Molecular Psychiatry·Lauren Allen, Yogesh Dwivedi
May 5, 2020·The International Journal of Neuropsychopharmacology·Bill QiYannis J Trakadis
Oct 30, 2018·Experimental & Molecular Medicine·Yun-Qiang WanXiao-Bin Wang
Jan 7, 2019·BMC Dermatology·Mariya AksenenkoTatiana Ruksha
Apr 14, 2019·Molecular Psychiatry·Angélica Torres-BerríoCecilia Flores
Nov 19, 2019·Frontiers in Molecular Neuroscience·Hai-Liang YanZhao-Qian Teng
Oct 28, 2017·Current Opinion in Psychiatry·Juan Pablo LopezGustavo Turecki
Jan 12, 2020·Current Topics in Medicinal Chemistry·Abhishek WadhawanTeodor T Postolache
Jun 6, 2020·Frontiers in Psychiatry·Maria Salud García-GutiérrezJorge Manzanares
Apr 19, 2020·Molecular Diagnosis & Therapy·Bhaskar RoyYogesh Dwivedi
Oct 7, 2020·Obesity·Hartej GillRoger S Mcintyre
Aug 30, 2020·Cells·Sherin SaheeraPrasanna Krishnamurthy
Nov 25, 2020·Developmental Cognitive Neuroscience·Kinga GawlińskaEdmund Przegaliński
Dec 22, 2020·Neurobiology of Stress·Li-Tao YiQing Liu
Oct 27, 2020·Frontiers in Psychiatry·Yuta Yoshino, Yogesh Dwivedi
Mar 1, 2021·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Chenggui Miao, Jun Chang
Aug 3, 2018·Journal of Affective Disorders·Yogesh Dwivedi
Jan 2, 2021·Biological Psychiatry·Angélica Torres-BerríoCecilia Flores
Apr 4, 2021·Journal of Personalized Medicine·Piotr CzarnyTomasz Sliwinski
May 3, 2021·Seminars in Cell & Developmental Biology·Alice Morgunova, Cecilia Flores
Aug 8, 2021·International Journal of Molecular Sciences·Hsiuying Wang
Aug 21, 2021·Journal of Neural Transmission·Helena Kyunghee KimStefan Kloiber
Aug 23, 2021·Translational Psychiatry·Laura M FioriGustavo Turecki
Sep 5, 2021·Translational Psychiatry·Chaoli HuangChun Yang

❮ Previous
Next ❯

Datasets Mentioned

BETA
GSE97154

Methods Mentioned

BETA
PCR
transfection
Chip

Clinical Trials Mentioned

NCT00635219
NCT00599911
NCT01140906
NCT01655706

Software Mentioned

Bioconductor
RNAHybrid
Bowtie
DESeq2 package
QuantStudio Real - Time PCR
DIANA
TarBase
Fastx
RNA22
SAMSeq

Related Concepts

Related Feeds

Alzheimer's Disease: RNA Sequencing

RNA sequencing studies have shed light on the genetic and molecular mechanisms related to the pathophysiology of Alzheimer's disease (AD). This feed follows papers using RNA sequencing technologies in Alzheimer's research.

Alzheimer's Disease: Transcription

Impaired transcription is associated with the pathogenesis and progression of conditions such as Alzheimer's disease (AD). Here are the latest discoveries pertaining to transcription and AD.