PMID: 18719380Aug 23, 2008Paper

microRNAs and cancer: an overview

Cell Cycle
Pedro P Medina, Frank J Slack

Abstract

MicroRNAs (miRNAs) are a recently discovered class of small RNA molecules that negatively regulate gene expression at the post-transcriptional level. MiRNAs play key roles in development and establishment of cell identity and aberrant metabolism/expression of miRNAs has been linked to human diseases including cancer. Components of the miRNA machinery and miRNAs themselves are involved in many cellular processes that are altered in cancer, such as differentiation, proliferation and apoptosis. Some miRNAs exhibit differential expression levels in cancer and have demonstrated capability to affect cellular transformation, carcinogenesis and metastasis acting either as oncogenes or tumour suppressors. We are only beginning to comprehend the functional repercussions of the gain or loss of particular microRNAs on cancer. Nonetheless, although microRNAs have been discovered in humans a mere eight years ago, a host of promising potential applications in the diagnosis, prognoses and therapy of cancer are emerging at a rapid pace.

Citations

Nov 7, 2012·Surgery Today·Isamu Hoshino, Hisahiro Matsubara
Jun 11, 2010·Breast Cancer Research and Treatment·Yingchun ZhaoGary Guishan Xiao
Nov 12, 2010·Clinical & Experimental Metastasis·Boye Schnack NielsenHans Jørgen Nielsen
May 10, 2011·Molecular and Cellular Biochemistry·Yanjie GuoJianing Zhang
Oct 13, 2009·Molecular Biology Reports·Hamed R GoodarziMohammad R Noori Daloii
May 20, 2009·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M Sánchez-Céspedes
Apr 29, 2011·Gene Therapy·J A Broderick, P D Zamore
Jan 1, 2009·Nature Methods·Pedro P Medina, Frank J Slack
Mar 4, 2011·Proceedings of the National Academy of Sciences of the United States of America·Sonia MeloManel Esteller
Feb 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Yukio Kawahara, Ai Mieda-Sato
Jun 10, 2010·The Journal of Biological Chemistry·Koichi WatashiKuan-Teh Jeang
Sep 10, 2010·The Journal of Biological Chemistry·Hongping XiaMarie C Lin
Mar 20, 2010·Nucleic Acids Research·Christina BackesAndreas Keller
Nov 28, 2012·Nucleic Acids Research·Anindya BhattacharyaYan Cui
Feb 25, 2010·Cancer Research·William M MerrittAnil K Sood
May 19, 2011·Cancer Research·Thalia A FaraziThomas Tuschl
Jan 16, 2010·BMC Bioinformatics·Anders JacobsenMorten Lindow
Jan 27, 2012·BMC Cancer·Ernesto Soto-ReyesLuis A Herrera
Jan 26, 2010·PloS One·Lea H GregersenAnders H Lund
Sep 21, 2011·Genetics and Molecular Biology·Edenir Inês PalmeroMarcia Maria C Marques
Dec 1, 2009·Epigenomics·Igor P Pogribny
Aug 29, 2013·BioMed Research International·Zhiyong ZhangTieqiao Wen

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