microRNAs and cardiac stem cells in heart development and disease

Drug Discovery Today
Bo LiLubo Zhang

Abstract

Cumulative evidence has proven that proliferation, differentiation and migration of cardiac stem cells (CSCs) dominate early heart development and contribute to the later occurrence of heart disease. Among other mechanisms, microRNAs work as the 'fine-tuning' to modulate the levels of target genes in a specific cell type. The distinct microRNA signatures in CSCs reveal the stages and functions of CSCs. The focus of this review is to summarize recent knowledge advances in CSC proliferation, differentiation and migration and to discuss how microRNAs regulate these processes during heart development and in heart disease. Better understanding of microRNA regulation on CSCs under different situations will enable the unveiling of the mechanisms of heart disease and open new avenues in the therapeutic potentials of microRNA modulation to treat heart disease.

Citations

Dec 14, 2018·Cells·Miruna Mihaela MicheuMaria Dorobantu
Apr 26, 2019·Genesis : the Journal of Genetics and Development·Yuji Nakajima
Nov 27, 2019·Cells·Rui SongLubo Zhang
Sep 5, 2019·American Journal of Physiology. Cell Physiology·Sébastien BonnetShizuka Uchida
Apr 10, 2020·Frontiers in Immunology·Jing Wang, Bo Han

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