MicroRNAs and cardiovascular medicine

SAGE Open Medicine
Upinder KaurB L Pandey

Abstract

MicroRNAs are non-coding RNA sequences that act as regulators of gene expression. They are aberrantly expressed in many pathological conditions. Cardiovascular diseases are among the leading causes of morbidity and mortality in the general population. Various knock-in and knockdown approaches have shown abnormal signature patterns of microRNAs in cardiovascular conditions like cardiac hypertrophy, myocardial infarction, heart failure, arrhythmias and vascular proliferative diseases. Since a single microRNA targets many genes, modulating a single microRNA involved in a disease carries a possible risk of undesirable side effects. The review focuses on current understanding of microRNAs in cardiovascular conditions, the possible underlying mechanisms and various approaches of modulating microRNAs.

References

Mar 10, 2000·Journal of Cardiovascular Electrophysiology·H J Jongsma
Apr 14, 2000·Circulation Research·J E SaffitzK A Yamada
Feb 28, 2004·Cardiology·Imran S SyedTodd K Rosengart
Feb 5, 2005·Trends in Biochemical Sciences·Guiliang Tang
Feb 26, 2005·Arteriosclerosis, Thrombosis, and Vascular Biology·Menno P J de WintherMarten H Hofker
Mar 15, 2005·The Journal of Clinical Investigation·Timothy A McKinsey, Eric N Olson
Sep 3, 2005·The Journal of Clinical Investigation·Yumei ZhanPeter Oettgen
May 6, 2006·The Journal of Biological Chemistry·Mickey M MartinTerry S Elton
Jul 20, 2006·Blood·Laura PolisenoGiuseppe Rainaldi
Nov 17, 2006·Proceedings of the National Academy of Sciences of the United States of America·Eva van RooijEric N Olson
Nov 17, 2006·Cancer Research·Carmen J MarsitKarl T Kelsey
Jan 20, 2007·Circulation Research·Danish SayedMaha Abdellatif
Mar 9, 2007·The Journal of Biological Chemistry·Jiening XiaoZhiguo Wang
Mar 24, 2007·Circulation Research·Yajaira SuárezWilliam C Sessa
May 1, 2007·Nature Medicine·Alessandra CarèGianluigi Condorelli
May 26, 2007·The American Journal of Pathology·Yunhui ChengChunxiang Zhang
Jun 26, 2007·Nature·J Graham RubyDavid P Bartel
Jul 4, 2007·Circulation·Thomas ThumJohann Bauersachs
Aug 19, 2007·Nature Methods·Margaret S EbertPhillip A Sharp
Oct 25, 2007·Nature Clinical Practice. Nephrology·Vesna D Garovic, Suzanne R Hayman
Jan 17, 2008·Nature Reviews. Genetics·Witold FilipowiczNahum Sonenberg
Jan 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Tamia A HarrisCharles J Lowenstein
Mar 29, 2008·Cancer Gene Therapy·A W Tong, J Nemunaitis
Apr 1, 2008·American Journal of Physiology. Heart and Circulatory Physiology·An L MoensDavid A Kass
Jun 13, 2008·Nature·Brandi N DavisAkiko Hata
Jun 28, 2008·Journal of Molecular and Cellular Cardiology·Carmen SucharovJ David Port
Aug 13, 2008·Developmental Cell·Jason E FishDeepak Srivastava
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Eva van RooijEric N Olson
Oct 25, 2008·Circulation Research·Eva van RooijEric N Olson

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Citations

Aug 22, 2021·Ecotoxicology and Environmental Safety·Qingping LiuRong Zhang

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Methods Mentioned

BETA
antisense oligonucleotides
nuclear translocation

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