MicroRNAs and their role in environmental chemical carcinogenesis

Environmental Geochemistry and Health
Minghui LiXijin Xu

Abstract

MicroRNAs (miRNAs) are a class of small, noncoding RNA species that play crucial roles across many biological processes and in the pathogenesis of major diseases, including cancer. Recent studies suggest that the expression of miRNA is altered by certain environmental chemicals, including metals, organic pollutants, cigarette smoke, pesticides and carcinogenic drugs. In addition, extensive studies have indicated the existence and importance of miRNA in different cancers, suggesting that cancer-related miRNAs could serve as potential markers for chemically induced cancers. The altered expression of miRNA was considered to be a vital pathogenic role in xenobiotic-induced cancer development. However, the significance of miRNA in the etiology of cancer and the exact mechanisms by which environmental factors alter miRNA expression remain relatively unexplored. Hence, understanding the interaction of miRNAs with environmental chemicals will provide important information on mechanisms underlying the pathogenesis of chemically induced cancers, and effectively diagnose and treat human cancers resulting from chronic or acute carcinogen exposure. This study presents the current evidence that the miRNA deregulation induced by various chemi...Continue Reading

References

Oct 4, 2007·Inhalation Toxicology·Charles Ris
Oct 28, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Alberto IzzottiSilvio De Flora
Dec 17, 2008·Clinical Lung Cancer·Steven G GrayKenneth J O'Byrne
Jan 22, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ai-Yu GongXian-Ming Chen
Jan 27, 2009·Proceedings of the National Academy of Sciences of the United States of America·Frank SchembriAvrum Spira
Mar 10, 2009·Environmental Health Perspectives·Baohong Zhang, Xiaoping Pan
May 14, 2009·Journal of Experimental & Clinical Cancer Research : CR·Tao YuXin-zhu Yi
Jul 21, 2009·Biochemical Society Transactions·S Duygu SelcukluCharles Spillane
Dec 19, 2009·Environmental Health Perspectives·Mark J NieuwenhuijsenMireille B Toledano
Dec 25, 2009·Journal of Cancer Research and Clinical Oncology·Xiao-Yan HeHui-min Peng
Feb 23, 2010·Nature Cell Biology·Li MaRobert A Weinberg
Apr 2, 2010·The Journal of Investigative Dermatology·Stefano CaramutaWeng-Onn Lui
Apr 27, 2010·Reproductive Toxicology·Michele Avissar-WhitingCarmen J Marsit
Sep 18, 2010·Clinical Chemistry·Jessica A WeberKai Wang
Sep 22, 2010·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yan CaoRui-Hua An
Oct 5, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Yiguo JiangYao Zhao
Oct 7, 2010·Cancer Research·Eran ElyakimNoga Yerushalmi
Nov 30, 2010·Molecular and Cellular Neurosciences·Gaelle LachenalRémy Sadoul
May 24, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Wataru YoshiokaChiharu Tohyama
Jul 13, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Kazumori KawakamiMasayuki Nakagawa
Jul 14, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Kevin BeezholdFei Chen
Jul 15, 2011·The Journal of Clinical Endocrinology and Metabolism·Vincenza LeoneAlfredo Fusco
Sep 15, 2011·Reproductive Biology and Endocrinology : RB&E·Jin-Sung ChoiSeokjoo Yoon
Nov 4, 2011·Toxicological Sciences : an Official Journal of the Society of Toxicology·Daochuan LiWen Chen
Dec 1, 2009·Epigenomics·Igor P Pogribny
Mar 10, 2012·PloS One·Syreeta L TilghmanMatthew E Burow
Jun 26, 2012·Environmental Toxicology and Pharmacology·Xinna LiRonggui Li

❮ Previous
Next ❯

Citations

Jul 17, 2020·Cancer Cell International·Dapeng ZhangXin Chen
Sep 24, 2020·International Journal of Environmental Health Research·Kaili ZouXiaoli Fu
Mar 11, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Martyn T SmithMark Fielden
Jan 23, 2021·Journal of Personalized Medicine·Michal SimaPavel Rossner
Apr 9, 2021·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Bin WuXingming Cai

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
Brock HumphriesChengfeng Yang
Trends in Cancer
Veronica BalattiCarlo M Croce
International Journal of Hygiene and Environmental Health
A Izzotti, A Pulliero
World Journal of Gastroenterology : WJG
Hong-Xia Fan, Hua Tang
© 2022 Meta ULC. All rights reserved