MicroRNAs are associated with blood-pressure effects of exposure to particulate matter: Results from a mediated moderation analysis

Environmental Research
Valeria MottaValentina Bollati

Abstract

Exposure to particulate air pollution is associated with increased blood pressure (BP), a well-established risk factor for cardiovascular disease. To elucidate the mechanisms underlying this relationship, we investigated whether the effects of particulate matter of less than 10μm in aerodynamic diameter (PM10) on BP are mediated by microRNAs. We recruited 90 obese individuals and we assessed their PM10 exposure 24 and 48h before the recruitment day. We performed multivariate linear regression models to investigate the effects of PM10 on BP. Using the TaqMan® Low-Density Array, we experimentally evaluated and technically validated the expression levels of 377 human miRNAs in peripheral blood. We developed a mediated moderation analysis to estimate the proportion of PM10 effects on BP that was mediated by miRNA expression. PM10 exposure 24 and 48h before the recruitment day was associated with increased systolic BP (β=1.22mmHg, P=0.019; β=1.24mmHg, P=0.019, respectively) and diastolic BP (β=0.67mmHg, P=0.044; β=0.91mmHg, P=0.007, respectively). We identified nine miRNAs associated with PM10 levels 48h after exposure. A conditional indirect effect (CIE=-0.1431) of PM10 on diastolic BP, which was mediated by microRNA-101, was found...Continue Reading

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Citations

Jul 28, 2016·Environmental Health : a Global Access Science Source·Annette VriensMichelle Plusquin
Oct 27, 2018·Current Environmental Health Reports·Rossella AlfanoMichelle Plusquin
Oct 22, 2016·Reviews on Environmental Health·Nina Holland
Apr 5, 2020·Antioxidants & Redox Signaling·Thomas MünzelAndreas Daiber
Jul 30, 2020·International Journal of Environmental Health Research·B HermanovaR J Sram
Jun 9, 2020·Molecular Biology Reports·Miruna-Mihaela MicheuIon-Andrei Nita
Jun 1, 2017·Antioxidants & Redox Signaling·Verónica MiguelSantiago Lamas
Jan 23, 2021·Journal of Personalized Medicine·Michal SimaPavel Rossner
Jul 30, 2020·Redox Biology·Verónica MiguelCristina Espinosa-Diez
Sep 10, 2021·Environmental Science and Pollution Research International·Suranjana MukherjeeKoel Chaudhury
Oct 7, 2021·Scientific Reports·Viyey Doulatram-GamgaramGemma Rojo-Martínez

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Methods Mentioned

BETA
PCR

Software Mentioned

Ingenuity Pathway Analysis ( IPA )
TLDA
Tox Lists analysis
SAS

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