MicroRNAs are Critical Regulators of Osteoclast Differentiation

Current Molecular Biology Reports
Henry C HrdlickaAnne M Delany

Abstract

Our goal is to comprehensively review the most recent reports of microRNA (miRNA) regulation of osteoclastogenesis. We highlight validated miRNA-target interactions and their place in the signaling networks controlling osteoclast differentiation and function. Using unbiased approaches to identify miRNAs of interest and reporter-3'UTR assays to validate interactions, recent studies have elucidated the impact of specific miRNA-mRNA interactions during in vitro osteoclastogenesis. There has been a focus on signaling mediators downstream of the RANK and CSF1R signaling, and genes essential for differentiation and function. For example, several miRNAs directly and indirectly target the master osteoclast transcription factor, Nfatc1 (e.g. miR-124 and miR-214) and Rho-GTPases, Cdc42 and Rac1 (e.g. miR-29 family). Validating miRNA expression patterns, targets, and impact in osteoclasts and other skeletal cells is critical for understanding basic bone biology and for fulfilling the therapeutic potential of miRNA-based strategies in the treatment bone diseases.

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Citations

Aug 26, 2020·In Vitro Cellular & Developmental Biology. Animal·Yingji MaoPinghui Zhou
Sep 11, 2020·Stem Cells International·Yi ZhaoWeiran Li
Jan 30, 2020·Frontiers in Pharmacology·Xin YanJia-Kuo Yu
Dec 18, 2020·Frontiers in Cell and Developmental Biology·Hanxiao ZhaoXiaojuan He
Nov 20, 2020·Bone·Megan M WeivodaDavid G Monroe
May 19, 2021·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·John GarciaAnne M Delany
Jun 3, 2021·International Journal of Molecular Sciences·Yen-Zung WuChung-Hwan Chen

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Methods Mentioned

BETA
nuclear translocation
ubiquitination
GTPase

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