MicroRNAs as Biomarkers in Cancer

Diagnostics
Kamini SundarboseSubbaya Subramanian

Abstract

MicroRNAs (miRNAs) are small non-coding RNA molecules, which in recent years have emerged to have enormous potential as biomarkers. Recently, there have been significant developments in understanding miRNA biogenesis, their regulatory mechanisms and role in disease process, and their potential as effective therapies. The identification of miRNAs as biomarkers provides possibilities for development of less or non-invasive and more specific methods for monitoring tumor growth and progression. This review summarizes the recent developments in methods to detect and quantitate miRNAs in body fluids and their applications as biomarkers in cancers. The prospect of miRNAs as potential diagnostic and prognostic biomarkers with clinical applications is significant as more evidence points to their central role in cancer pathobiology.

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Citations

Jan 9, 2014·BMC Genomics·Jianmin SuYong Zhang
Feb 11, 2020·Radiation and Environmental Biophysics·Francesca PasiRosanna Nano
Sep 25, 2017·Engineering in Life Sciences·Stefan SchmiederFrank Sonntag
Sep 19, 2020·International Journal of Molecular Sciences·Ishita GuptaHalema Al Farsi
Aug 25, 2021·Seminars in Cancer Biology·Lin WangBing-Hua Jiang

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Methods Mentioned

BETA
transfection
imaging
biopsy
immunoprecipitation
PCR

Software Mentioned

miRCURY

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