MicroRNAs as biomarkers of harmful environmental and occupational exposures: a systematic review

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
Michail Kotsyfakis, Evridiki Patelarou

Abstract

Environmental exposure is a growing public health burden associated with several negative health effects. An estimated 4.2 million deaths occur each year from ambient air pollution alone. Biomarkers that reflect specific exposures have the potential to measure the real integrated internal dose from all routes of complex environmental exposure. MicroRNAs (miRNAs), small non-coding RNAs that regulate gene expression, have been studied as biomarkers in various diseases and have also shown potential as environmental exposure biomarkers. Here, we review the available human epidemiological and experimental evidence of miRNA expression changes in response to specific environmental exposures including airborne particulate matter. In doing so, we establish that miRNA exposure biomarker development remains in its infancy and future studies will need to carefully consider biological and analytical 'design rules' in order to facilitate clinical translation.

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Citations

Mar 14, 2020·Current Environmental Health Reports·Alison H Harrill, Alison P Sanders
Jul 23, 2020·Environmental Pollution·Naga Raju MaddelaMallavarapu Megharaj
Jan 23, 2021·Journal of Personalized Medicine·Michal SimaPavel Rossner
Feb 13, 2021·International Journal of Environmental Research and Public Health·Giovanni ImbrianiAntonella De Donno
Mar 7, 2021·Journal of Personalized Medicine·Deborah TraversiStefania Boccia
Mar 9, 2021·Frontiers in Genetics·Marília Ladeira de AraújoGustavo Rafael Mazzaron Barcelos
Mar 8, 2021·Toxicological Sciences : an Official Journal of the Society of Toxicology·Anke M TukkerKimberly A McAllister
Jul 3, 2021·International Journal of Environmental Research and Public Health·Steffen MuellerShujun Liu

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