MicroRNAs in diabetic wound healing: Pathophysiology and therapeutic opportunities

Trends in Cardiovascular Medicine
Denizhan Ozdemir, Mark W Feinberg

Abstract

Diabetic wound healing is an incompletely understood pathophysiological state. It comprises a range of potentially devastating and common complications of diabetes mellitus (DM) leading to intractable infections, lower extremity amputations, and associated cardiovascular morbidity and mortality. MicroRNAs (miRNAs) have emerged as important regulators in various physiological processes in health and disease through their ability to fine-tune cellular responses. Herein, we summarize the versatile roles of miRNAs implicated in diabetic wound healing in key stages including inflammation, angiogenesis, re-epithelialization, and remodeling. Furthermore, we highlight current evidence through which miRNAs exert control of gene expression and signaling pathways in the reparative response that may provide opportunities for therapeutic intervention for this potentially devastating disease state.

Citations

May 18, 2019·Drug Development and Industrial Pharmacy·S Bernal-ChávezA Ganem-Rondero
Jan 23, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Basak IcliMark W Feinberg
Jun 5, 2020·Advances in Wound Care·Adam G BergerPaula T Hammond
May 14, 2020·Journal of Dermatological Science·Enke BaldiniTeresa Odorisio
May 4, 2021·Seminars in Cell & Developmental Biology·Raza Ali NaqviAfsar R Naqvi
Aug 16, 2021·Journal of Biochemical and Molecular Toxicology·Tianfeng ZhengJun Tian
Aug 27, 2021·Bioorganic & Medicinal Chemistry Letters·Xue LiGang Chen

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