MicroRNAs in dysfunctional adipose tissue: cardiovascular implications

Cardiovascular Research
Basak Icli, Mark W Feinberg

Abstract

In this review, we focus on the emerging role of microRNAs, non-coding RNAs that regulate gene expression and signaling pathways, in dysfunctional adipose tissue. We highlight current paradigms of microRNAs involved in adipose differentiation and function in depots such as white, brown, and beige adipose tissues and potential implications of microRNA dysregulation in human disease such as obesity, inflammation, microvasculature dysfunction, and related cardiovascular diseases. We highlight accumulating studies indicating that adipocyte-derived microRNAs may not only serve as biomarkers of cardiometabolic disease, but also may directly regulate gene expression of other tissues. Finally, we discuss the future prospects, challenges, and emerging strategies for microRNA delivery and targeting for therapeutic applications in cardiovascular disease states associated with adipocyte dysfunction.

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Citations

Nov 1, 2017·Antioxidants & Redox Signaling·Ioannis Akoumianakis, Charalambos Antoniades
Nov 27, 2018·Cardiovascular Research·Heather Y Small, Tomasz J Guzik
Mar 25, 2019·Cardiovascular Research·Rosalinda MadonnaRaffaele De Caterina
Apr 28, 2020·Clinical Science·Marianna SantopaoloPaolo Madeddu
Aug 30, 2017·Frontiers in Cardiovascular Medicine·Manna LiJian Xu
Oct 6, 2018·Nature Reviews. Cardiology·Evangelos K Oikonomou, Charalambos Antoniades
Sep 11, 2020·Computational and Mathematical Methods in Medicine·Baoliang ZhuJing Yan
Sep 24, 2020·International Journal of Molecular Sciences·Sabel MeadowsNalini Santanam
Feb 27, 2018·Cardiovascular Research·Jesper Bäckdahl, Mikael Rydén
Nov 8, 2019·Cardiovascular Research·Heather Y Small, Tomasz J Guzik
Feb 7, 2021·Scientific Reports·Adam CornwellJuilee Thakar
Nov 20, 2020·Cells·Seley GharaneiHarpal S Randeva
Apr 19, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Huifeng YuanXinwei Han

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