MicroRNAs in Liver Disease: Bench to Bedside

Journal of Clinical and Experimental Hepatology
Nihar ShahKris V Kowdley

Abstract

MicroRNAs (miRs) are small non-coding RNAs that negatively regulate gene expression by pairing with partially complementary target sequences in the 3'UTRs of mRNAs to promote degradation and/or block translation. Aberrant miR expression is associated with development of multiple diseases including hepatic diseases. The role of miRs in the regulation of gene expression and rapid progress in the field of microRNA research are resulting in momentum toward development of diagnostic markers and novel therapeutic strategies for human liver diseases. Recent studies provide clear evidence that miRs are abundant in the liver and modulate a diverse spectrum of biological functions, thereby supporting an association between alterations of miR homeostasis and pathological liver diseases. Here we review the role of miRs in liver as their physiological and pathological importance has been demonstrated in metabolism, immunity, viral hepatitis, oncogenesis, fatty liver diseases (alcoholic and non-alcoholic), drug-induced liver injury, fibrosis as well as acute liver failure.

Citations

Aug 5, 2018·Journal of Cellular Physiology·Tao XuJun Li
Mar 5, 2016·Frontiers in Pharmacology·Hans-Theo SchonRalf Weiskirchen
Sep 16, 2016·Journal of Digestive Diseases·Xiao Lin LiuJian Gao Fan
Feb 28, 2016·Digestive Diseases and Sciences·Helen L ReevesChristopher P Day
Dec 2, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Avishek Kumar SinghShiv Kumar Sarin
Jul 23, 2015·Wiley Interdisciplinary Reviews. RNA·Wei LiuHao Ying
Dec 28, 2016·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Jing-Jing YangJun Li

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