MicroRNAs in Liver Regeneration

Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
Xiaoyu ChenChangqing Yang

Abstract

Liver maintains a unique tremendous regeneration capacity in response to partial hepatectomy (PH) or injury. Hepatocyte proliferation critically contributes to the process of liver regeneration (LR), which is regulated by various cytokines and growth factors. However, the molecular basis of LR remains unclear. Emerging evidence indicates that microRNAs (miRNAs, miRs) are involved in controlling hepatocyte proliferation during LR. In this review, an overview is provided to cover recent achievements in studies on the roles of miRNAs in LR. Studies on the regulatory effects of miRNAs and associated molecular mechanisms in LR will help enhance the understanding of the regenerative process and open up a new prospect for liver transplantation.

Citations

May 14, 2016·Journal of Clinical Medicine·Amar Mahgoub, Clifford J Steer
Mar 9, 2019·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·I CapobiancoA Königsrainer
Mar 30, 2019·Wiley Interdisciplinary Reviews. Developmental Biology·Anan Abu RmilahScott L Nyberg
May 24, 2017·Molecular Medicine Reports·Menggang Liu, Ping Chen
Apr 6, 2021·World Journal of Hepatology·Yana V KiselevaYuri O Zharikov

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