MicroRNAs in pathogenesis, diagnosis, and treatment of gastroesophageal cancers

Gastroenterology
Jee Hoon Song, Stephen J Meltzer

Abstract

The incidence of gastroesophageal cancers is increasing each year, but despite much research, their molecular mechanisms are incompletely understood. microRNAs (miRNAs) are noncoding RNAs that have been associated with gastroesophageal carcinogenesis. We review the involvement of miRNAs in gastric and esophageal cancers and their mechanisms of regulation, effects on gene expression, and biological functions. Many miRNAs are dysregulated in gastroesophageal cancer cells via alterations in transcription, epigenetic features, or copy number of the genes that encode them. Each type of gastroesophageal tumor has a unique gene expression profile. miRNAs contribute to gastroesophageal carcinogenesis by altering expression of oncogenes and tumor suppressors to affect cell proliferation, apoptosis, and motility and invasion. A number of miRNAs, including circulating miRNAs, have been associated with tumor type or stage, or patient survival, and might be developed as diagnostic or prognostic markers. Greater understanding of the roles of miRNAs in gastroesophageal carcinogenesis could provide insights into the mechanisms of tumor development and identify therapeutic targets.

Associated Clinical Trials

References

Nov 1, 1995·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M OkaT Suzuki
May 15, 1998·Mayo Clinic Proceedings·A J Cameron
Aug 24, 2000·International Journal of Cancer. Journal International Du Cancer·A PajicD Eick
Mar 5, 2002·Gastroenterology·Douglas A CorleyPatricia A Buffler
Mar 22, 2002·The Lancet Oncology·D M Parkin
Jun 4, 2002·Nature Reviews. Genetics·Peter A Jones, Stephen B Baylin
Jun 18, 2003·Cell·Yigong Shi, Joan Massagué
Oct 22, 2003·Cell·Dianne S SchwarzPhillip D Zamore
Dec 6, 2003·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ralf BaumannHans-Uwe Simon
Dec 6, 2003·The New England Journal of Medicine·Peter C Enzinger, Robert J Mayer
Feb 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·George Adrian CalinCarlo M Croce
Sep 17, 2004·The EMBO Journal·Yoontae LeeV Narry Kim
Dec 16, 2004·World Journal of Surgery·Christophe MarietteJean Pierre Triboulet
May 14, 2005·Nucleic Acids Research·Yael AltuviaHanah Margalit
Jun 10, 2005·Nature·Jun LuTodd R Golub
Oct 28, 2005·The New England Journal of Medicine·George Adrian CalinCarlo M Croce
Dec 17, 2005·Cancer Biology & Therapy·Yizeng YangJonathan P Katz
Feb 18, 2006·Science·Antonio J GiraldezAlexander F Schier
Feb 24, 2006·Proceedings of the National Academy of Sciences of the United States of America·Ligang WuJoel G Belasco
Apr 25, 2006·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Prateek SharmaRichard E Sampliner
Jul 4, 2006·Genes & Development·Isabelle Behm-AnsmantElisa Izaurralde
Aug 3, 2006·Genes & Development·J Michael ThomsonScott M Hammond
Nov 14, 2006·Nature Structural & Molecular Biology·Glen M BorchertBeverly L Davidson
Dec 23, 2006·Seminars in Radiation Oncology·J Rüdiger Siewert, Katja Ott
Jan 27, 2007·The EMBO Journal·Young-Kook Kim, V Narry Kim
Feb 1, 2007·Journal of Cell Science·Tamara CavannaDaniel Zicha
Feb 20, 2007·Cancer Research·Amaia LujambioManel Esteller
May 31, 2007·Proceedings of the National Academy of Sciences of the United States of America·J Robin LytleJoan A Steitz
Feb 5, 2008·The Journal of Thoracic and Cardiovascular Surgery·Andrew FeberVirginia R Litle
Apr 29, 2008·Advances in Experimental Medicine and Biology·Yongjun FanCéline Gélinas
May 2, 2008·International Journal of Cancer. Journal International Du Cancer·Lin XiaDaiming Fan

❮ Previous
Next ❯

Citations

Nov 21, 2012·Nature Reviews. Gastroenterology & Hepatology·Shumei Song, Jaffer A Ajani
Aug 9, 2013·International Journal of Molecular Sciences·Xiangsheng LiHua Yang
Apr 20, 2013·World Journal of Gastroenterology : WJG·Ming GaoZhe-Wei Fei
Jan 25, 2014·Expert Reviews in Molecular Medicine·Hua-Hsi WuKuo-Wang Tsai
Aug 20, 2014·Nature Reviews. Gastroenterology & Hepatology·Mairi H McLean, Emad M El-Omar
Jul 29, 2015·Critical Reviews in Clinical Laboratory Sciences·Ravnit GrewalCiprian Tomuleasa
Jun 5, 2015·International Journal of Cancer. Journal International Du Cancer·Takatsugu IshimotoPatrick Tan
Oct 8, 2013·Expert Opinion on Medical Diagnostics·Patrick S PlumUte Warnecke-Eberz
Feb 9, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xuesong WuFeng Sun
Apr 23, 2013·Current Problems in Surgery·David Estores, Vic Velanovich
May 4, 2013·Gastroenterology Clinics of North America·Dushant S Uppal, Steven M Powell
Feb 13, 2013·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hao YangLianyue Yang
Jun 16, 2015·Gastroenterology·Patrick Tan, Khay-Guan Yeoh
Mar 20, 2014·International Journal of Cancer. Journal International Du Cancer·Yolanda Espinosa-ParrillaNúria Sala
Aug 12, 2014·CA: a Cancer Journal for Clinicians·Ioana Berindan-NeagoeGeorge A Calin
Feb 1, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiangxiang WanJunming Guo
Jul 21, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Xiaoyun DingJunming Guo
Jan 28, 2016·The American Journal of Surgical Pathology·Bita V NainiRobert D Odze
Apr 19, 2015·World Journal of Surgical Oncology·Zhujiang ZhaoHong Fan
Jan 9, 2015·Current Treatment Options in Gastroenterology·Meghan Jankowski, Sachin Wani
Feb 9, 2016·The Journal of Reproduction and Development·Pinar Tulay, Sioban B Sengupta
Jun 21, 2016·International Journal of Molecular Sciences·Ming-Ming TsaiKwang-Huei Lin
Oct 6, 2016·Journal of Cancer Research and Clinical Oncology·Cheng-Zuo XiaoRong-Ping Guo
Jul 1, 2016·Expert Opinion on Therapeutic Targets·Chun-Xia RenDong-Qing Ye
Jan 30, 2016·Journal of Gastroenterology and Hepatology·Soo-Kyung ParkSeung-Jae Myung
Jan 12, 2017·Cancer Medicine·Olusola O FaluyiGeoffrey Liu
Aug 26, 2017·Expert Review of Gastroenterology & Hepatology·Wanli YangLiu Hong

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Checkpoints & Regulators

Cell cycle checkpoints are a series of complex checkpoint mechanisms that detect DNA abnormalities and ensure that DNA replication and repair are complete before cell division. They are primarily regulated by cyclins, cyclin-dependent kinases, and the anaphase-promoting complex/cyclosome. Here is the latest research.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Cancer Epigenetics & Methyl-CpG (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. Here is the latest research on cancer epigenetics and methyl-CpG binding proteins including ZBTB38.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cancer Epigenetics

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cancer Genomics (Keystone)

Cancer genomics approaches employ high-throughput technologies to identify the complete catalog of somatic alterations that characterize the genome, transcriptome and epigenome of cohorts of tumor samples. Discover the latest research using such technologies in this feed.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Cell Signaling & Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. This feed covers the latest research on signaling and epigenetics in cell growth and cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Barrett Esophagus

Barrett’s esophagus if a serious complication of gastroesophageal reflux disease during which the normal esophageal lining changes to tissue that resembles intestinal lining. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Cancer Epigenetics (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. Here is the latest research on cancer epigenetics.

Cancer Epigenetics & Metabolism (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may or may not provide advantages for the cancer cells. This feed focuses on the relationship between cell metabolism, epigenetics and tumor differentiation.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Atrophic Gastritis

Atrophic Gastritis is a process where gastric glandular cells are lost and replaced with firbous tissues, as a result of chronic inflammation. Learn more about Atrophic Gastritis here.

Cell Cycle Pathways

Cell cycle is a complex process regulated by several signal transduction pathways and enzymes. Here is the latest research on regulation of cell cycle and cell cycle pathways.

Cancer Epigenetics and Senescence (Keystone)

Epigenetic changes are present and dysregulated in many cancers, including DNA methylation, non-coding RNA segments and post-translational protein modifications. The epigenetic changes may be involved in regulating senescence in cancer cells. This feed captures the latest research on cancer epigenetics and senescence.

Related Papers

Frontiers in Cellular and Infection Microbiology
Jennifer M Noto, Richard M Peek
Nature Reviews. Gastroenterology & Hepatology
Shumei Song, Jaffer A Ajani
Current Opinion in Pharmacology
Stefan David, Stephen J Meltzer
Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus
S-Q LiX-F Cao
© 2021 Meta ULC. All rights reserved