MicroRNAs in patients on chronic hemodialysis (MINOS study).

Clinical Journal of the American Society of Nephrology : CJASN
Cristina EmilianDaniel R Wagner

Abstract

Diagnosis of acute myocardial injury with biomarkers is difficult in patients with advanced renal failure. Circulating microRNAs are promising new biomarkers of myocardial injury. It is unknown whether levels of microRNAs are affected in patients undergoing hemodialysis. High-sensitivity cardiac troponin T (hsTnT) and cardiac-enriched miR-499 were measured in 41 patients with ESRD undergoing hemodialysis and 41 controls. Levels of hsTnT and miR-499 were highly elevated in patients with ESRD compared with controls (>80-fold increase; P<0.001). Among patients with ESRD, 98% had positive hsTnT levels and 46% had positive miR-499 levels. Levels of troponins were not affected by hemodialysis. However, miR-499 levels were decreased after hemodialysis (6.5-fold decrease; P=0.002). Both miR-499 and troponins are elevated in patients with advanced renal failure. However, whereas levels of troponins are unaffected by hemodialysis, this is not the case for miR-499. Therefore, these observations mitigate the potential of miR-499 as a marker of myocardial injury in patients with ESRD.

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Citations

Jun 21, 2012·PloS One·Filippo MartinoThomas Thum
Apr 4, 2013·Biomarkers in Medicine·Adam PleisterTerry S Elton
Dec 19, 2013·Journal of Internal Medicine·Y DevauxC Mueller
Oct 23, 2016·British Journal of Clinical Pharmacology·Laura RivoliJames W Dear
Aug 31, 2013·Circulation Research·Regalla Kumarswamy, Thomas Thum
Dec 10, 2019·American Journal of Physiology. Renal Physiology·Axel MuendleinHeinz Drexel
Oct 25, 2017·Hemodialysis International·Magdi El SharkawyDina Usama
Oct 11, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Bogusz TrojanowiczMatthias Girndt
Jun 24, 2017·Clinical Kidney Journal·Alexander Hüttenhofer, Gert Mayer
Jun 6, 2020·Cell Biochemistry and Function·Kumaresan Ramanathan, Giri Padmanabhan
Jun 2, 2020·Frontiers in Pharmacology·Timo Brandenburger, Johan M Lorenzen

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