Abstract
Diagnosis of acute myocardial injury with biomarkers is difficult in patients with advanced renal failure. Circulating microRNAs are promising new biomarkers of myocardial injury. It is unknown whether levels of microRNAs are affected in patients undergoing hemodialysis. High-sensitivity cardiac troponin T (hsTnT) and cardiac-enriched miR-499 were measured in 41 patients with ESRD undergoing hemodialysis and 41 controls. Levels of hsTnT and miR-499 were highly elevated in patients with ESRD compared with controls (>80-fold increase; P<0.001). Among patients with ESRD, 98% had positive hsTnT levels and 46% had positive miR-499 levels. Levels of troponins were not affected by hemodialysis. However, miR-499 levels were decreased after hemodialysis (6.5-fold decrease; P=0.002). Both miR-499 and troponins are elevated in patients with advanced renal failure. However, whereas levels of troponins are unaffected by hemodialysis, this is not the case for miR-499. Therefore, these observations mitigate the potential of miR-499 as a marker of myocardial injury in patients with ESRD.
References
Oct 18, 2000·Circulation·J DierkesC Luley
Aug 11, 2001·Clinica Chimica Acta; International Journal of Clinical Chemistry·S FredericksD W Holt
Dec 4, 2002·Circulation·Christian W HammHugo A Katus
Dec 31, 2002·Journal of the American College of Cardiology·Benjamin J FredaGary S Francis
Sep 17, 2004·Nature·Victor Ambros
Mar 7, 2008·Journal of the American Society of Nephrology : JASN·Angela Yee-Moon Wang, Kar-Neng Lai
Aug 28, 2009·The New England Journal of Medicine·Tobias ReichlinChristian Mueller
Feb 18, 2010·European Heart Journal·Guo-Kun WangQing Jing
Apr 17, 2010·Clinical Chemistry·Taichi AdachiNaoharu Iwai
Jun 11, 2010·European Heart Journal·Yuri D'AlessandraMaurizio C Capogrossi
Oct 6, 2010·Circulation. Cardiovascular Genetics·Maarten F CorstenBlanche Schroen
Jun 28, 2011·Cardiology·Olof GidlöfDavid Erlinge
Aug 3, 2011·Journal of Molecular and Cellular Cardiology·Christian WideraThomas Thum
Oct 4, 2011·Journal of the American College of Cardiology·Allan S JaffeFred S Apple
Jan 19, 2012·Clinical Chemistry·Yvan DevauxDaniel R Wagner
Citations
Jun 21, 2012·PloS One·Filippo MartinoThomas Thum
May 30, 2013·PloS One·Neal X ChenSharon M Moe
Apr 4, 2013·Biomarkers in Medicine·Adam PleisterTerry S Elton
Dec 19, 2013·Journal of Internal Medicine·Y DevauxC Mueller
Oct 15, 2014·PloS One·Ping WenJunwei Yang
Oct 23, 2016·British Journal of Clinical Pharmacology·Laura RivoliJames W Dear
Aug 31, 2013·Circulation Research·Regalla Kumarswamy, Thomas Thum
Dec 10, 2019·American Journal of Physiology. Renal Physiology·Axel MuendleinHeinz Drexel
Oct 25, 2017·Hemodialysis International·Magdi El SharkawyDina Usama
Oct 11, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Bogusz TrojanowiczMatthias Girndt
Jun 24, 2017·Clinical Kidney Journal·Alexander Hüttenhofer, Gert Mayer
Jun 6, 2020·Cell Biochemistry and Function·Kumaresan Ramanathan, Giri Padmanabhan
Jun 15, 2017·PloS One·Marcin DziedzicJanusz Solski
Oct 3, 2018·Archives of Physiology and Biochemistry·Manal S FawzyEman A Toraih
Jun 2, 2020·Frontiers in Pharmacology·Timo Brandenburger, Johan M Lorenzen
Jan 7, 2019·BMC Cardiovascular Disorders·Tong SuXun Li
Jun 25, 2019·Cardiorenal Medicine·Tong SuXun Li