MicroRNAs in rheumatoid arthritis

Clinical Rheumatology
Eisa SalehiKatayoon Bidad

Abstract

The role of genetic and epigenetic factors in the development of rheumatic diseases has been an interesting field of research over the past decades all around the world. Research on the role of microRNAs (miRNAs) in rheumatoid arthritis (RA) has been active and ongoing, and investigations have attempted to use miRNAs as biomarkers in disease diagnosis, prognosis, and treatment. This review focuses on experimental researches in the field of miRNAs and RA to present the data available up to this date and includes researches searched by keywords "microRNA" and "rheumatoid arthritis" in PubMed from 2008 to January 2015. All references were also searched for related papers. miRNAs are shown to act as proinflammatory or anti-inflammatory agents in diverse cell types, and their role seems to be regulatory in most instances. Researchers have evaluated miRNAs in patients compared to controls or have investigated their role by overexpressing or silencing them. Multiple targets have been identified in vivo, in vitro, or in silico, and the researches still continue to show their efficacy in clinical settings.

References

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Citations

Apr 3, 2016·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jessica M SidoMitzi Nagarkatti
Jul 15, 2015·Autoimmunity Reviews·Alexey V ChurovMikael Knip
Aug 26, 2016·Arthritis Research & Therapy·Bart V J CuppenUNKNOWN all SRU investigators
Jun 13, 2018·Clinical and Experimental Immunology·M DunaevaG J M Pruijn
Mar 12, 2019·Journal of Cellular Biochemistry·Yiyue ChenLele Liao
Jun 3, 2020·International Journal of Molecular Sciences·Nilay MitashAgnieszka Swiatecka-Urban
Jul 21, 2017·Clinical Rheumatology·Patricia Castro-Santos, Roberto Díaz-Peña
Aug 19, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Nahid AkhtarSalahuddin Ahmed
Aug 3, 2020·Molecular Biology Reports·S Reyes-LongA Alfaro-Rodríguez
May 23, 2018·Journal of Immunology Research·Maria Cristina Moran-MoguelMaria G Zavala-Cerna
Jul 2, 2019·Frontiers in Genetics·Marina V NemtsovaAndrey A Zamyatnin
Dec 11, 2020·Bone·Johannes GrillariMatthias Hackl
Feb 7, 2021·Auto- Immunity Highlights·Mohammad Javad MousaviMahdi Mahmoudi
Oct 30, 2020·Autoimmunity Reviews·Greta PaciniMaurizio Cutolo
Jun 19, 2021·Life Sciences·Sina KhodakarimiAbbas Ebrahimi-Kalan
Jul 27, 2021·International Journal of Clinical Practice·Omayma O AbdelaleemRania H Mahmoud

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