MicroRNAs in the Cholangiopathies: Pathogenesis, Diagnosis, and Treatment

Journal of Clinical Medicine
Maria Jose Lorenzo PisarelloNicholas F LaRusso

Abstract

The cholangiopathies are a group of liver diseases resulting from different etiologies but with the cholangiocyte as the primary target. As a group, the cholangiopathies result in significant morbidity and mortality and represent one of the main indications for liver transplant in both children and adults. Contributing to this situation is the absence of a thorough understanding of their pathogenesis and a lack of adequate diagnostic and prognostic biomarkers. MicroRNAs are small non-coding RNAs that modify gene expression post-transcriptionally. They have been implicated in the pathogenesis of many diseases, including the cholangiopathies. Thus, in this review we provide an overview of the literature on miRNAs in the cholangiopathies and discuss future research directions.

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Citations

Nov 28, 2016·Journal of Bioenergetics and Biomembranes·Kui TuYu Cao
Sep 3, 2017·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zhenhua LuoJorge A Bezerra
Dec 17, 2017·Oncotarget·Bo ZhengQiang Xia
Feb 7, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Adrian P MansiniSergio A Gradilone
Oct 22, 2016·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jiabei WangLianxin Liu
May 28, 2020·International Journal of Molecular Sciences·Priscilla R PrestesFadi J Charchar
May 29, 2021·Environmental Science and Pollution Research International·Marwa M MahmoudNadia M Hamdy

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Methods Mentioned

BETA
transfection
surgical resection
confocal microscopy

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