MicroRNAs involved in the EGFR pathway in glioblastoma

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Bin XuJunfei Shao


Glioblastoma (GBM) is the most common primary malignant tumor in adults, and its morbidity and mortality are very high. Although progress has been achieved in the treatment of GBM, such as surgery, chemotherapy and radiotherapy, in recent years, the prognosis of patients with GBM has not improved significantly. MicroRNAs (miRNAs) are endogenous noncoding single-stranded RNAs consisting of approximately 20-22 nucleotides that regulate gene expression at the posttranscriptional level by binding to target protein-encoding mRNAs. Notably, miRNAs regulate various carcinogenic pathways, one of which is the epidermal growth factor receptor (EGFR) signaling pathway, which controls cell proliferation, invasion, migration, angiogenesis and apoptosis. In this review, we summarize the novel discoveries of roles for miRNAs targeting the factors in the EGFR signaling pathway in the occurrence and development of GBM. In addition, we describe their potential roles as biomarkers for the diagnosis and prognosis of GBM and for determining the treatment resistance of GBM and the efficacy of therapeutic drugs.


Sep 26, 2003·Nature·Yoontae LeeV Narry Kim
Jun 24, 2004·Nature Reviews. Genetics·Lin He, Gregory J Hannon
Sep 17, 2004·The EMBO Journal·Yoontae LeeV Narry Kim
Oct 17, 2008·Genes & Development·Martin Eilers, Robert N Eisenman
Feb 12, 2009·Current Opinion in Cell Biology·Nancy E Hynes, Gwen MacDonald
Jan 6, 2010·Laboratory Investigation; a Journal of Technical Methods and Pathology·Xuan ZhouChunsheng Kang
Jun 11, 2010·Annual Review of Biochemistry·Marc Robert FabianWitold Filipowicz
Sep 30, 2010·Cancer Investigation·Mark KatakowskiMichael Chopp
Jun 17, 2011·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Kyung Min LeeIn Ah Kim
Aug 30, 2011·Oncogene·T PapagiannakopoulosK S Kosik
Jan 20, 2012·Current Medicinal Chemistry·P RusconiM Broggini
Apr 10, 2012·European Journal of Pharmacology·Dimitry A Chistiakov, Vladimir P Chekhonin
May 25, 2012·Cell and Tissue Research·Mahboob Ul Hussain
May 22, 2013·PloS One·Soumya Alige Mahabala RaoKumaravel Somasundaram
Jul 19, 2013·Current Pharmaceutical Design·Deliang GuoArnab Chakravarti
Jul 25, 2013·The Plant Cell·Kestrel Rogers, Xuemei Chen
Dec 4, 2013·Trends in Cell Biology·Alejandra TomasEmily R Eden
May 29, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Fei WangYouhou Zhu
Oct 9, 2014·Advances in Biological Regulation·Mario AcunzoCarlo M Croce
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Apr 2, 2015·Oncotarget·Daquan HuangYing Peng
May 7, 2015·Science Signaling·Lijoy K MathewM Celeste Simon
Jul 4, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Fulin XuPifeng Jia
Dec 15, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hanchun ChenDongwei Dai
Feb 10, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Guiyan Xu, Jian Yi Li
Nov 9, 2016·Methods in Molecular Biology·Anchal Vishnoi, Sweta Rani
Mar 25, 2017·Cellular Signalling·Deirdre Duff, Aideen Long
Jul 21, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Junyi GuXiangdong Li
Aug 10, 2017·Methods in Molecular Biology·Zhixiang Wang
Dec 23, 2017·Cell Communication and Signaling : CCS·Daniela M Gomez ZubietaKalyan C Kondapalli
Dec 23, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yiqun ZhouRoger M Leblanc
Jan 9, 2018·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Yana GaoYixue Xue
Sep 1, 2016·Journal of Biomedical Nanotechnology·Yuan YinAnjana Jain
Apr 2, 2018·Biochemical and Biophysical Research Communications·Yanwei JiHaoran Hu
May 26, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hengyi FanYan Zhang
Jul 10, 2018·Briefings in Bioinformatics·Liang ChenGarry Wong
Jul 14, 2018·Cancer Biotherapy & Radiopharmaceuticals·Bo XuLiang Lai
Aug 18, 2018·Biochemical and Biophysical Research Communications·Ji-Yeon LeeMyoung Hee Kim
Oct 27, 2018·Journal of Cellular Physiology·Fatemeh VahidianBehzad Baradaran
Dec 1, 2018·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Robert Roskoski
Feb 8, 2019·Cancer Science·Ryou-U TakahashiTakahiro Ochiya
Feb 27, 2019·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Yuhui YuWei Wu
Aug 10, 2019·Biochimica Et Biophysica Acta. Reviews on Cancer·Fernanda Costa Brandão BertiDanielle Malheiros
Oct 29, 2019·Cancer Biotherapy & Radiopharmaceuticals·Lei ChenMengyi Huang
Jan 4, 2020·Clinical Neurology and Neurosurgery·Alireza TabibkhooeiAlireza Mohsenian
Jan 17, 2020·Cells·Ufuk DegirmenciJiancheng Hu
Mar 6, 2020·Life Sciences·Mohammad Mirza-Aghazadeh-AttariMaryam Majidinia

Related Concepts

Biological Markers
Malignant Neoplasms
Epidermal Growth Factor Receptor
RNA Processing, Post-Transcriptional
RNA, Messenger
Signal Pathways

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