MicroRNAs-mediated cell fate in triple negative breast cancers

Cancer Letters
Xinbing SuiHongming Pan

Abstract

MicroRNAs (miRNAs) are small non-coding RNAs that function as major modulators of posttranscriptional protein-coding gene expression in diverse biological processes including cell survival, cell cycle arrest, senescence, autophagy, and differentiation. The control of miRNAs plays an important role in cancer initiation and metastasis. Triple negative breast cancer (TNBC) is a distinct breast cancer subtype, which is defined by the absence of estrogen receptor (ER), progesterone receptor (PR) and epidermal growth factor receptor 2 (HER2/neu). Due to its high recurrence rate and poor prognosis, TNBC represents a challenge for breast cancer therapy. In recent years, a large number of microRNAs have been identified to play a crucial role in TNBC and some of them were found to be correlated with worse prognosis of TNBC. Thus, understanding the novel function of miRNAs may allow us to develop promising therapeutic targets for the treatment of TNBC patients.

References

Sep 13, 2001·Proceedings of the National Academy of Sciences of the United States of America·T SørlieA L Børresen-Dale
Jun 28, 2003·Proceedings of the National Academy of Sciences of the United States of America·Therese SorlieDavid Botstein
Jul 19, 2003·Science·James C Carrington, Victor Ambros
Sep 17, 2004·Nature·Victor Ambros
Oct 25, 2006·Nature Reviews. Cancer·George A Calin, Carlo M Croce
Jun 2, 2007·Molecular Cell·Tsung-Cheng ChangJoshua T Mendell
Jun 16, 2009·Cell·Scott ValastyanRobert A Weinberg
Sep 30, 2010·Nature Reviews. Clinical Oncology·Lisa CareyLuca Gianni
Feb 1, 2011·Journal of Molecular Cell Biology·Zhaohui FengWenwei Hu
Apr 20, 2011·Breast Cancer Research : BCR·Erin N HoweJennifer K Richer
May 19, 2011·Cancer Research·Thalia A FaraziThomas Tuschl
Aug 5, 2011·Breast Cancer Research and Treatment·Mark MackiewiczNatasha J Caplen
Nov 29, 2011·Cell·Elena PiskounovaRichard I Gregory
Mar 24, 2012·Diagnostic Pathology·Marek SvobodaRostislav Vyzula
May 15, 2012·Molecular Oncology·Claudia PiovanCarlo M Croce
May 29, 2012·Asian Pacific Journal of Cancer Prevention : APJCP·Shahram SavadMohammad Hossein Modarressi
Jun 2, 2012·The Lancet Oncology·Yi W KongMartin Bushell
Jun 21, 2012·Journal of Experimental & Clinical Cancer Research : CR·Chen WangYurong Shi
Aug 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·Christos PolytarchouKevin Struhl
Oct 4, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J CrownG Gullo
Dec 18, 2012·The Journal of Clinical Investigation·Molly A TaylorWilliam P Schiemann
Feb 23, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Hailing LiuXi-ru Li
May 10, 2013·Cell Cycle·Andrea BissoGiannino Del Sal
Jun 28, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Jian-Yi LiPi-Song Li
Oct 26, 2013·RNA·Keerthana KrishnanNicole Cloonan
Nov 30, 2013·Cancer Treatment Reviews·Danila SerpicoSerena Di Cosimo
Dec 4, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nicholas C Turner, Jorge S Reis-Filho
Mar 22, 2014·Expert Review of Molecular Diagnostics·Laoighse MulraneDarran P O'Connor
May 3, 2014·Cell Death and Differentiation·A PaulS Paul

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Citations

Jan 16, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Bairong XiaGe Lou
Apr 26, 2016·International Journal of Molecular Sciences·Li ZhangLianfeng Zhang
Dec 14, 2016·Future Medicinal Chemistry·Francesca Aredia, Anna Ivana Scovassi
Aug 19, 2017·Journal of Cell Science·Jinhang HuLufeng Zheng
Mar 31, 2016·Food Science and Biotechnology·Jin-Wook KangJeong-Sang Lee
May 29, 2020·Technology in Cancer Research & Treatment·Guochen ZhangXiangdong Bai
Nov 21, 2020·Photodiagnosis and Photodynamic Therapy·María Guadalupe Cupido-SánchezEva Ramón-Gallegos

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