MicroRNAs (MiRs) Precisely Regulate Immune System Development and Function in Immunosenescence Process

International Reviews of Immunology
Seyed Hossein Aalaei-andabili, Nima Rezaei

Abstract

Human aging is a complex process with pivotal changes in gene expression of biological pathways. Immune system dysfunction has been recognized as one of the most important abnormalities induced by senescent names immunosenescence. Emerging evidences suggest miR role in immunosenescence. We aimed to systemically review all relevant reports to clearly state miR effects on immunosenescence process. Sensitive electronic searches carried out. Quality assessment has been performed. Since majority of the included studies were laboratory works, and therefore heterogen, we discussed miR effects on immunological aging process nonstatically. Forty-six articles were found in the initial search. After exclusion of 34 articles, 12 studies enrolled to the final stage. We found that miRs have crucial roles in exact function of immune system. MiRs are involved in the regulation of the aging process in the immune system components and target certain genes, promoting or inhibiting immune system reaction to invasion. Also, miRs control life span of the immune system members by regulation of the genes involved in the apoptosis. Interestingly, we found that immunosenescence is controllable by proper manipulation of the various miRs expression. DNA m...Continue Reading

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Citations

Jun 28, 2017·Experimental Gerontology·Jose Coelho-Lima, Ioakim Spyridopoulos
Aug 12, 2017·International Reviews of Immunology·Jonathon KeckBernard P Arulanandam
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Feb 6, 2020·Frontiers in Pharmacology·Dong HanJianfei Nao
Aug 18, 2021·Ocular Immunology and Inflammation·Jiankang ShanLiping Du

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