MicroRNAs modulating angiogenesis: miR-129-1 and miR-133 act as angio-miR in HUVECs

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Mina Soufi-ZomorrodMasoud Soleimani

Abstract

The sprouting of new blood vessels by angiogenesis is critical in vascular development and homeostasis. Aberrant angiogenesis leads to enormous pathological conditions such as ischemia and cancer. MicroRNAs (also known as miRNAs or miRs) play key roles in regulation of a range of cellular processes by posttranscriptional suppression of their target genes. Recently, new studies have indicated that miRNAs are involved in certain angiogenic settings and signaling pathways use these non-coding RNAs to promote or suppress angiogenic processes. Herein, VEGFR2 and FGFR1 were identified as miR-129-1 and miR-133 targets using bioinformatic algorithms, respectively. Afterwards, using luciferase reporter assay and gene expression analysis at both mRNA and protein levels, VEGFR2 and FGFR1 were validated as miR-129-1 and miR-133 targets. In addition, we showed that miR-129-1 and miR-133 suppress angiogenesis properties such as proliferation rate, cell viability, and migration activity of human umbilical vein endothelial cells (HUVEC) in vitro. We conclude that these miRNAs can suppress key factors of angiogenesis by directly targeting them. These results have important therapeutic implications for a variety of diseases involving deregulatio...Continue Reading

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Citations

Jul 1, 2016·Cardiovascular Research·Rokas NavickasPaul Holvoet
Nov 2, 2017·Journal of Cellular Biochemistry·Homeira Javadi PiroozFatemeh Kouhkan
Apr 16, 2019·Cell Transplantation·Yi XiaoGuolong Yu
Jun 3, 2020·International Journal of Molecular Sciences·Kevin GlaeselVerena Theis
Jan 18, 2017·BioMed Research International·Xiao LinYou-Shuo Liu
Apr 23, 2020·Molecular Medicine Reports·Yishen WangYan Luo
Nov 11, 2019·International Journal of Molecular Sciences·Alexey ChurovAlexander Orekhov
Dec 23, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Gang WangMao Luo
Jan 28, 2021·Immunological Investigations·Yeping LuoZuocheng Yang
Feb 10, 2021·International Journal of Environmental Research and Public Health·Agnė ŠatrauskienėPaul Holvoet
Jun 13, 2021·Journal of Cellular and Molecular Medicine·Kévin BassandHanna Hlawaty

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